Microbiology of nutrigenomics

营养基因组学微生物学

• 批准号: 1000229066-2013
• 负责人: Willing, Benjamin
• 金额: $ 3.64万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=668646
• 关键词: Microbiology; nutrigenomics

The gastrointestinal tract of all animals is populated with an abundant and complex community of bacteria, archaea, protozoa and fungi, collectively termed microbiota. Imbalances in microbiota, or dysbiosis, contribute to the most important health issues facing modern medicine including diabetes, heart disease, cancer, asthma, and inflammatory bowel disease, among others. Microbes metabolize the food we eat, resulting in the production of diverse molecules that act on host cells contributing to health and disease. I am investigating how select microbes affect the production of these bioactive molecules by systematically removing bacterial populations from the gut. We will measure how changes in microbial population affect the production bioactive molecules and change host physiology. In characterizing fundamentals of microbe-mammalian interaction we will expand the understanding of how changes in the microbiota impact the host and promote health.

所有动物的胃肠道都充满了丰富而复杂的细菌、古细菌、原生动物和真菌群落，统称为微生物群。微生物群的不平衡或生态失调导致了现代医学面临的最重要的健康问题，包括糖尿病，心脏病，癌症，哮喘和炎症性肠病等。微生物代谢我们吃的食物，导致产生不同的分子，作用于宿主细胞，促进健康和疾病。我正在研究如何选择微生物影响这些生物活性分子的生产，系统地从肠道中清除细菌种群。我们将测量微生物种群的变化如何影响生物活性分子的产生并改变宿主生理。在表征微生物与哺乳动物相互作用的基本原理时，我们将扩大对微生物群变化如何影响宿主和促进健康的理解。