Red Osier Dogwood extracts as alternatives to in-feed antibiotics to enhance growth performance and gut health in broiler chickens

禽肉的消费一直在增加，主要是因为它对健康有益、烹饪方便、** *和价格合理。2010年，全球食用动物生产中抗微生物药物的消费量估计为63151吨，并有增加趋势。这种做法与抗微生物药物耐药性病原体在家禽和人类中的传播有关，对公共卫生构成重大威胁。自2006年以来，欧盟已**禁止在动物食品生产中使用抗生素生长促进剂，预计加拿大也将很快实施这一禁令。目前有必要帮助家禽业准备和实施减少抗生素的使用/消除加拿大预防性使用抗生素。红狗企业有限公司决定与杨氏实验室合作，研究红叶山茱萸提取物作为饲料中抗生素的替代品，以提高肉鸡的生长性能和肠道健康。对于当前的项目，已经确立了两个具体目标**。在目的1中，我们将测定饲喂不同水平红山茱萸提取物的肉鸡的生长性能、器官重量和白剥率。在**目的2中，我们将研究饲喂不同水平红叶茱萸提取物的**肉鸡在沙门氏菌脂多糖**刺激后的免疫反应、肠道菌群、氧化应激和炎症反应。拟议的Engage项目将支持初步研究，并在红**狗企业有限公司和杨实验室之间建立桥梁关系。这笔资金将产生关于假定机制的新知识，这些机制可能构成未来伙伴关系计划应用（即NSERC CRD）的基础。

The consumption of poultry meat has been increasing mainly due to its health benefit, convenience in cooking,**and reasonable cost. Global consumption of antimicrobials in food animal production was estimated at 63,151**tons in 2010 with an increasing trend. This practice has been linked to the spread of antimicrobial-resistant**pathogens in both poultry and humans, posing a significant public health threat. The European Union has**banned the use of antibiotic growth promoters in animal food production since 2006 and this is expected in**Canada soon. There is an on-going need to help the poultry industry prepare for and implement the reduced use**of antibiotics/elimination of the preventive use of antibiotics in Canada. Red Dog Enterprises Ltd. has decided**to partner with the Yang lab to investigate Red Osier Dogwood extracts as alternatives to in-feed antibiotics to**enhance growth performance and gut health in broiler chickens. For the current project, two specific objectives**have been established. For Objective 1, we will determine the growth performance, organ weights and**occurrence of white stripping of broiler chickens fed different levels of Red Osier Dogwood extracts. For**Objective 2, we will determine the immune response, gut microbiota, oxidative stress, and inflammation in**broiler chickens fed different levels of Red Osier Dogwood extracts after Salmonella Lipopolysaccharide**challenge. The proposed Engage project will support preliminary research and bridge relations between Red**Dog Enterprises Ltd. and the Yang laboratory. This funds will yield new knowledge about putative**mechanisms that may form the basis of future partnership program applications (ie: NSERC CRD).