Red Osier Dogwood extracts as alternatives to in-feed antibiotics to enhance growth performance and gut health in broiler chickens

红柳山茱萸提取物作为饲料抗生素的替代品，可提高肉鸡的生长性能和肠道健康

• 批准号: 523472-2018
• 负责人: Yang, Chengbo
• 金额: $ 1.82万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669152
• 关键词: Red; Osier; Dogwood; extracts; alternatives

The consumption of poultry meat has been increasing mainly due to its health benefit, convenience in cooking,**and reasonable cost. Global consumption of antimicrobials in food animal production was estimated at 63,151**tons in 2010 with an increasing trend. This practice has been linked to the spread of antimicrobial-resistant**pathogens in both poultry and humans, posing a significant public health threat. The European Union has**banned the use of antibiotic growth promoters in animal food production since 2006 and this is expected in**Canada soon. There is an on-going need to help the poultry industry prepare for and implement the reduced use**of antibiotics/elimination of the preventive use of antibiotics in Canada. Red Dog Enterprises Ltd. has decided**to partner with the Yang lab to investigate Red Osier Dogwood extracts as alternatives to in-feed antibiotics to**enhance growth performance and gut health in broiler chickens. For the current project, two specific objectives**have been established. For Objective 1, we will determine the growth performance, organ weights and**occurrence of white stripping of broiler chickens fed different levels of Red Osier Dogwood extracts. For**Objective 2, we will determine the immune response, gut microbiota, oxidative stress, and inflammation in**broiler chickens fed different levels of Red Osier Dogwood extracts after Salmonella Lipopolysaccharide**challenge. The proposed Engage project will support preliminary research and bridge relations between Red**Dog Enterprises Ltd. and the Yang laboratory. This funds will yield new knowledge about putative**mechanisms that may form the basis of future partnership program applications (ie: NSERC CRD).

禽肉的消费量一直在增加，主要是由于其健康益处，烹饪方便，价格合理。2010年，全球食用动物生产中的抗菌剂消费量估计为63，151 ** 吨，且呈增长趋势。这种做法与耐抗生素病原体在家禽和人类中的传播有关，构成了重大的公共卫生威胁。自2006年以来，欧盟已经禁止在动物食品生产中使用抗生素生长促进剂，预计加拿大很快也会这样做。在加拿大，持续需要帮助家禽业准备和实施减少抗生素使用/消除预防性使用抗生素。Red Dog Enterprises Ltd.已决定 ** 与Yang实验室合作，研究Red Osier Dogwood提取物作为饲料抗生素的替代品，以 ** 提高肉鸡的生长性能和肠道健康。本项目确定了两个具体目标 **。对于目标1，我们将确定饲喂不同水平的红柳山茱萸提取物的肉鸡的生长性能、器官重量和 ** 发生白色剥离。对于 ** 目标2，我们将确定沙门氏菌脂多糖 ** 攻击后饲喂不同水平红柳山茱萸提取物的 ** 肉鸡的免疫应答、肠道微生物群、氧化应激和炎症。拟议的Engage项目将支持Red**Dog Enterprises Ltd.和Yang实验室之间的初步研究和桥梁关系。该基金将产生关于推定的 ** 机制的新知识，这些机制可能构成未来伙伴关系计划应用的基础（即：NSERC CRD）。