Influence of altered sensory input and Cortical Asymmetry on Movement Induced Plasticity

我的研究重点是了解神经可塑性的差异，当运动技能的获得发生在存在改变的感觉输入，以及大脑功能的偏侧化和手的偏好因素。适应性（有益的）可塑性增强运动学习和表现;而适应不良（有害的）可塑性导致错误的运动模式，降低运动表现的速度和准确性，并造成潜在的伤害。在职业、娱乐或运动环境中，我们经常在学习新的运动技能的同时存在外部感官刺激，如振动或疼痛。这项发现补助金解决了如何改变感觉输入，如疼痛，影响运动诱导的可塑性是适应性还是适应不良。手的优势或偏侧性是终身使用依赖性可塑性的模型，本研究还试图了解支配（Dom）和非支配（NonDom）肢体之间的运动控制差异如何影响运动训练中适应性或适应不良可塑性的潜力 * 我的长期目标是推进我们对影响运动训练诱导可塑性的因素的基本理解。我的短期目标是：1）探索在运动获得任务中改变感觉输入导致感觉运动可塑性增强或受损的神经机制; 2）当操纵任务要求以有利于肢体动力学的预测或阻抗控制时，比较Dom和NonDom肢体的感觉运动反应确定在存在疼痛的情况下进行运动序列采集时，Dom和NonDom肢体之间是否存在差异。**新奇和影响：我的创新方法将促进我们对运动训练期间感觉中断如何增强或干扰使用依赖性可塑性的理解。这是基础知识，因为我们经常在学习新的运动技能时，会出现外部的感觉刺激，如振动或疼痛。在我们的现代世界中，技术的使用意味着我们不断被要求掌握新的运动技能，而且我们经常被要求使用双手。了解运动技能获得的神经机制中的半球差异是至关重要的，这样技术设计的进步就会导致适应性可塑性，而不是适应不良的可塑性和损伤。调查因素，可能有助于我们的适应性可塑性的能力是至关重要的，在这个时代的现代技术的使用，并具有重要的意义，人体工程学和康复。

My research is focused on understanding differences in neural plasticity when motor skill acquisition occurs in the presence of altered sensory inputs, and how lateralization of brain function and hand preference factor into this. Adaptive (beneficial) plasticity enhances motor learning and performance; while maladaptive (harmful) plasticity leads to faulty movement patterns, decreasing speed and accuracy of motor performance, and creating the potential for injury. In occupational, recreational or sporting contexts, we are often learning new motor skills while extraneous sensory stimuli such as vibration or pain are present. This Discovery Grant addresses how altered sensory inputs such as pain, influence whether movement induced plasticity is adaptive or maladaptive. Hand dominance or laterality is a model of lifelong use-dependent plasticity and this research also seeks to understand how motor control differences between the Dominant (Dom) and non-dominant (NonDom) limbs influences the potential for adaptive or maladaptive plasticity in response to motor training ******My long term goal is to advance our fundamental understanding of the factors that influence motor training induced plasticity. My short term objectives are: 1) explore the neural mechanisms by which altered sensory input during motor acquisition tasks leads to either enhanced or impaired sensorimotor plasticity; 2) Compare sensorimotor responses of the Dom and NonDom limbs when task requirements are manipulated to favour either predictive or impedance control of limb dynamics 3) Determine whether there are differences between the Dom and NonDom limbs when motor sequence acquisition takes place in the presence of pain.******Novelty and Impact: My innovative approach will advance our understanding of how sensory disruptions during motor training either enhance or interfere with use-dependent plasticity. This is fundamental knowledge because we are often learning new motor skills while extraneous sensory stimuli such as vibration or pain are present. In our modern world, technology use has meant that we are constantly called upon to master novel motor skills, and often we are called upon to use both hands. It is critical to understand hemispheric differences in neural mechanisms of motor skill acquisition so that advances in technology design lead to adaptive plasticity rather than to maladaptive plasticity and injury. Investigating factors which may contribute to our capacity for adaptive plasticity is critical in this era of modern technology use, and has important implications for both ergonomics and rehabilitation.