Exploring enzyme immobilization on two-dimensional nanomaterials**

探索酶在二维纳米材料上的固定化**

• 批准号: 533711-2018
• 负责人: Zarrin, Hadis
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669583
• 关键词: Exploring; enzyme; immobilization; two; dimensional

Enzyme immobilization is considered a powerful tool for enhancing enzymatic properties such as stability and reusability for advanced nanobiotechnological applications. However, the lack of a stable and biocompatible platform without compromising the activity of enzymes is impeding the wide utilization of enzymes in different industries (e.g, medical, coating and paint, smart textiles, food packaging, marine, etc.). The Zarrin group at Ryerson University is focused on the design and development of biocompatible and stable 2D nanostructured supports via green and eco-friendly techniques for different types of organic and biological molecules. Inorganic 2D nanomaterials (e.g., MoS2, boron nitride, etc.) offer promising eco-friendly platforms for regulating enzyme modulation by providing large surface areas for biomolecule adsorption and being engineered to form multifunctional structures for better interactions with biomolecules. Biosa Technologies Limited (Biosa) is an expert in providing enzymatic technological solutions for improving the properties, stability and efficiency of enzymes, providing increased reusability. This Engage grant will enable Biosa and the Ryerson team to begin working towards successfully integrating all the required enzymatic properties into a single multifunctional nanomaterial. As a result, many Canadian and global enzymatic and biotechnology industries can save in capital costs on materials and improve their product quality.

酶固定化被认为是提高酶性质的有力工具，如用于先进的纳米生物技术应用的稳定性和可重用性。然而，在不影响酶活性的情况下缺乏稳定的生物兼容平台阻碍了酶在不同行业(如医疗、涂料和涂料、智能纺织品、食品包装、海洋等)的广泛应用。Ryerson大学的Zarrin团队致力于通过绿色环保技术为不同类型的有机和生物分子设计和开发生物兼容和稳定的2D纳米结构支撑物。无机2D纳米材料(如MoS2、氮化硼等)通过提供更大的生物分子吸附表面积和形成多功能结构以更好地与生物分子相互作用，为调节酶的调节提供了有前景的生态友好型平台。BioSA Technologies Limited(BioSA)是一家提供酶技术解决方案的专家，旨在提高酶的性能、稳定性和效率，提高可重用性。这笔Engage赠款将使BioSA和Ryerson团队能够开始努力，成功地将所有所需的酶特性集成到单一的多功能纳米材料中。因此，许多加拿大和全球的酶和生物技术行业可以节省材料的资本成本，并提高产品质量。