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Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality.

Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality.
聚 (ADP-核糖) 写入器、读取器和擦除器:在 DNA 双链断裂修复和合成致死中发挥作用。
批准号:
400856
负责人:
Poirier Guy G
金额:
$69.66万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-03-01 至 2024-03-01

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中文摘要
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英文摘要
Inhibition of poly(ADP-ribose) polymerase (PARP) proteins, which cells use in a variety of DNA damage repair mechanisms, is a promising therapy for cancers. Because cancer cells often have preexisting defects in DNA damage repair pathways, the inhibition
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Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy
  • 批准号:
    488326
  • 项目类别:
    Operating Grants
  • 资助金额:
    $75.24万
  • 财政年份:
    2023
  • 负责人:
    Poirier Guy G
  • 依托单位:
Functions of poly(ADP-ribose) polymerases in DNA double-strand break processing and pathway choice
Molecular mechanisms of cell death induced by poly(ADP-ribosyl)ation
  • 批准号:
    189171
  • 项目类别:
    Operating Grants
  • 资助金额:
    $45.87万
  • 财政年份:
    2009
  • 负责人:
    Poirier Guy G
  • 依托单位:
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
  • 批准号:
    204193
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2008
  • 负责人:
    Poirier Guy G
  • 依托单位:
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