Role of extracellular ATP in bone adaptation to mechanical environment

细胞外 ATP 在骨适应机械环境中的作用

• 批准号: 400436
• 负责人: Komarova Svetlana V
• 金额: $ 41.8万
• 依托单位: Shriners Hospital for Children (Montral)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=400436&lang=en
• 关键词: Aging; Atp; Bone; Calcium Signaling; Exercise; Injury; Mechanical Forces; Osteoblast; P2 Receptors; Repair

Physical forces are critical for successful function of many organs including bone; however, they also have a destructive potential. Many cell types, including bone cells, such as bone forming osteoblasts, sense and actively adapt to physical perturbation

物理力对于包括骨骼在内的许多器官的成功功能至关重要;然而，它们也具有破坏性潜力。许多细胞类型，包括骨细胞，如骨形成成骨细胞，感知并主动适应物理扰动