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Functional selectivity at the post-endocytic sorting of heptahelical receptors: focus on delta opioid receptor (DOR) recycling.

Functional selectivity at the post-endocytic sorting of heptahelical receptors: focus on delta opioid receptor (DOR) recycling.
七螺旋受体内吞后分选的功能选择性:关注 δ 阿片受体 (DOR) 回收。
批准号:
171297
负责人:
Pineyro Graciela
金额:
$41.37万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2008
资助国家:
加拿大
项目状态:
已结题
起止时间:
2008-09-01 至 2013-09-01

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中文摘要
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英文摘要
Heptahelical receptors are the target for more than 50% of currently available therapeutic aagents. These receptors are specialized membrane proteins that allow to convey information from the extracellular to intracellular space by undergoing conformation
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会议论文
"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".
Harnessing in vitro signaling diversity of opioid analgesics as a means of predicting in vivo development of tolerance
12 th Annual Meeting GPCR Retreat
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