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"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".

"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".
“迈向理想的阿片类镇痛药：通过新型功能选择性 MOR 激动剂提高耐受性”。
批准号：
370227
负责人：
Pineyro Graciela
金额：
$67.71万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370227&lang=en
关键词：
Analgesia Chronic Pain Gpcrs Opioid Receptors Opioids Quantitative Pharmacology Signaling Bias

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中文摘要
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英文摘要
Opioids are the most effective analgesics known and elective in the treatment of severe pain. However, they also produce severe side effects that limit their clinical use. Analgesia and undesired actions both arise from signals produced when opioids bind
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