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Targeting PI3-kinase p110delta to treat Crohn's disease-associated intestinal fibrosis

Targeting PI3-kinase p110delta to treat Crohn's disease-associated intestinal fibrosis
靶向 PI3 激酶 p110delta 治疗克罗恩病相关肠纤维化
批准号：
401340
负责人：
Sly Laura M
金额：
$69.66万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-03-01 至 2024-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401340&lang=en
关键词：
Animal Models Crohn'S Disease Inflammatory Bowel Disease Intestinal Fibrosis Intestinal Inflammation Pi3kp110delta Samp1/Yitfc Mice Ship

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中文摘要
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英文摘要
Inflammatory bowel disease (IBD) affects 1 in 140 Canadians. It is caused by inflammation along the gastrointestinal (GI) tract that can lead to symptoms including abdominal pain, vomiting, and diarrhea. There are two main types of IBD, Crohn's disease
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Crohn's Disease genetic variants predispose to commensal-driven autoinflammation
Macrophages in intestinal disease
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