Application of social cognitive theory to physical activity behavior among adults with Crohn's disease

社会认知理论在克罗恩病成人体力活动行为中的应用

• 批准号: 10745823
• 负责人: Whitney Neal
• 金额: $ 3.97万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-04 至 2025-12-03
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745823
• 关键词: Accelerometer; Adult; Affect; Age; Albumins; Area; Behavior; Behavioral; Biological; Biological Markers; C-reactive protein; CD6 antigen; Chronic; Chronic Disease; Clinical; Clinical Trials Design; Community Practice; Complex; Control Groups; Crohn' s disease; Development; Devices; Disease; Disease Outcome; Familiarity; Foundations; Future; General Population; Goals; Health Benefit; Health Care Costs; Health Promotion; Histologic; Individual; Inflammatory; Informal Social Control; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Leukocyte L1 Antigen Complex; Measures; Medical Records; Mentorship; Methodology; Mucous Membrane; Muscle function; Operative Surgical Procedures; Outcome; Participant; Patient Care; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physical activity; Physical assessment; Play; Population; Postoperative Period; Public Health; Questionnaires; Reporting; Research; Research Personnel; Research Proposals; Role; Sample Size; Sampling; Scientist; Self Assessment; Self Efficacy; Social support; Solid; Specificity; Statistical Methods; Surgeon; Testing; Therapeutic Effect; Training; Translating; Translational Research; Translations; Ulcerative Colitis; behavior change; cardiorespiratory fitness; career; clinical application; clinical practice; clinical remission; design; evidence base; exercise intervention; expectation; healing; improved; indexing; programs; psychosocial; responsible research conduct; sedentary; sedentary lifestyle; sex; skills; social cognitive theory; sound; therapy development; treatment program

PROJECT SUMMARY/ABSTRACT Crohn’s disease (CD), which affects over 500,000 individuals with CD in the US, is a chronic and uniquely challenging condition that requires lifelong medications, major surgeries, and health promotion. Physical activity (PA) is an essential component of many chronic disease and surgical treatment programs, but the potential benefits of PA in CD are poorly understood as there has been a paucity of research in CD. Identifying factors that influence PA participation and the extent and intensity regular PA has a therapeutic effect (i.e., inflammatory biomarkers, mucosal healing) on disease activity in CD is important for developing effective PA interventions that can be translated to practice. Therefore, the primary objective of this research proposal is to examine the complex behavioral and biological correlates of PA in CD. This project seeks to compare PA rates between adults with CD and healthy controls (Aim 1) and examine the psychosocial and clinical influences on self-report and device-measured PA (Aims 2 and 3) in CD. The central hypothesis is that adults with CD who report lower levels of self-efficacy engage in less device-measured PA and more sedentary behavior than the general population, and that the relationship between PA and disease outcomes varies by both volume and pattern of PA behavior and the aspect of disease activity measured. The public health significance of this study lies in its potential to develop an improved, theoretically sound understanding of PA behavior in CD and the relationship between PA and disease activity. These findings could potentially result in better designed, more effective PA programs for adults with CD that ultimately have the potential to reduce healthcare costs associated with adverse postoperative outcomes. My ultimate career goal is to lead a collaborative research team that bridges the gap between evidence-based PA interventions and the translation of this evidence into clinical and community practice in the context of CD. To better prepare myself for a career as an independent investigator, I am seeking training in 4 major areas: 1) rigorous research in the CD field, including familiarity with CD clinical patient care; 2) multidisciplinary collaboration with clinicians and scientists; 3) translational research, including clinical trial design, statistical methods, and interpretation of results for clinical application and future intervention development; and 4) professional development, including principles of scientific integrity and responsible conduct of research. Training in these areas is integral to completing the research aims and providing me with a solid foundation for a successful career as an independent researcher.

项目摘要/摘要 克罗恩病（CD）是一种慢性和独特的疾病，在美国影响超过50万CD患者。 具有挑战性的条件，需要终身药物治疗，大手术和健康促进。身体活动 (PA)是许多慢性病和手术治疗计划的重要组成部分，但潜在的 由于缺乏对CD的研究，因此对PA在CD中的益处知之甚少。识别因素 影响PA参与以及程度和强度的常规PA具有治疗效果（即，炎性 生物标志物，粘膜愈合）对CD疾病活动性的影响对于开发有效的PA干预措施非常重要 可以转化为实践。因此，本研究提案的主要目标是审查 PA在CD中的复杂行为和生物学相关性。该项目旨在比较PA率之间 成年CD患者和健康对照组（目标1），并检查心理社会和临床对自我报告的影响 和CD中的器械测量PA（目标2和3）。中心假设是，报告较低的CD成人 自我效能水平参与较少的设备测量PA和更多的久坐行为比一般 PA和疾病结局之间的关系因患者数量和模式而异。 PA的行为和疾病活动方面的测量。这项研究的公共卫生意义在于其 有可能发展一个改进的，理论上合理的理解PA的行为在CD和关系 PA和疾病活动之间的关系。这些发现可能会导致更好的设计，更有效的PA 为成人CD患者提供的计划，最终有可能降低与不良反应相关的医疗保健成本。 术后结果。我的最终职业目标是领导一个合作研究团队，弥合差距 基于证据的PA干预措施与将此证据转化为临床和社区之间的关系 在裁谈会的背景下。为了更好地为自己作为独立调查员的职业生涯做好准备，我正在寻求 4个主要方面的培训：1）在CD领域进行严格的研究，包括熟悉CD临床患者护理; 2)与临床医生和科学家的多学科合作; 3）转化研究，包括临床试验 临床应用和未来干预的设计、统计方法和结果解释 专业发展，包括科学诚信和负责任行为的原则 的研究。在这些领域的培训是不可或缺的，以完成研究目标，并为我提供了一个坚实的 作为一名独立研究人员的成功职业基础。