Manufacturing and scaling of an in vitro human skeletal muscle phenotypic assay

体外人类骨骼肌表型测定的制造和规模化

• 批准号: 544504-2019
• 负责人: Mcguigan, Alison
• 金额: $ 1.09万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=675590
• 关键词: Manufacturing; scaling; vitro; human; skeletal

We have created a human culture assay in a dish to study muscle stem-cell mediated muscle repair. This will enable us to identify factors and molecules that impact muscle repair (or lack of repair in a number of disease situations). Currently the translation of our platform from an academic setting into industrial use is limited by scaling both platform manufacturing and platform analysis. We seek i2i funds to establish a scalable manufacturing method and automated image analysis pipeline for our platform. In this Market Assessment application we seek i2i funds to assess the market for our platform, with a view to using this information as a basis for a stage 1 i2i application in the future.

我们在培养皿中进行了人类培养测定，以研究肌肉干细胞介导的肌肉修复。这将使我们能够识别影响肌肉修复（或在许多疾病情况下缺乏修复）的因素和分子。目前，我们的平台从学术环境到工业用途的转化受到平台制造和平台分析规模的限制。我们寻求 i2i 资金来为我们的平台建立可扩展的制造方法和自动图像分析管道。在此市场评估申请中，我们寻求 i2i 资金来评估我们平台的市场，以期将此信息用作未来第一阶段 i2i 申请的基础。