Revealing the Omnigenic Genetic Architecture of End Stage Renal Disease: Investigating the Cumulative Effect of Rare and Common Genetic Variants

揭示终末期肾病的全基因遗传结构：研究罕见和常见遗传变异的累积效应

• 批准号: 410054
• 负责人: Lanktree Matthew B
• 金额: $ 46.53万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=410054&lang=en
• 关键词: Chronic Kidney Disease; End-Stage Renal Disease; Exome Sequencing; Genome-Wide Association Studies; Mendelian Randomization; Polygenic Risk Scores; Population Biobanks And Databases; Rare Variant Burden Tests

Purpose: Kidney disease affects 1 in 10 Canadians. 35,000 Canadians currently have kidney failure needing dialysis or a kidney transplant. A cause for kidney failure is unknown in 50% of patients. Kidney disease does not make people unwell until it is adv

目的：肾脏疾病影响10个加拿大人中的1个。目前有35，000名加拿大人患有肾衰竭，需要透析或肾移植。50%的患者肾衰竭的原因不明。肾脏疾病直到晚期才会使人不适。