Mutation co-operativity in early tumorigenesis events of low-grade serous ovarian carcinoma: Lesson from an organoid model system and single-cell RNA-sequencing

低级别浆液性卵巢癌早期肿瘤发生事件中的突变协同性：类器官模型系统和单细胞 RNA 测序的教训

• 批准号: 412074
• 负责人: Zhang Joyce (Yu Han)
• 金额: $ 0.11万
• 依托单位: B.C. Cancer Research Centre (Vancouver)
• 依托单位国家: 加拿大
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2020-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=412074&lang=en
• 关键词: Diagnostic Markers; Ics Travel Awards; Modelling Tumorigenesis Events; Organoid Culture; Ovarian Cancer; Single-Cell Rna-Sequencing; Targeted Treatment Options

Ovarian cancer is the most common gynecologic cancer and the fifth leading cause of cancer death in women. Such poor outcome is due to lack of reliable early detection strategies and suboptimal response to chemotherapies. Our study focuses on a rare subty

卵巢癌是最常见的妇科癌症，也是女性癌症死亡的第五大原因。如此糟糕的结果是由于缺乏可靠的早期检测策略和对化疗的反应不佳造成的。我们的研究重点是一个罕见的微妙之处