Exploring the Role of Copper in Inducing an Anticancer Immune Response

探索铜在诱导抗癌免疫反应中的作用

• 批准号: 538302-2018
• 负责人: Sveinson, Kelly
• 金额: $ 1.82万
• 依托单位: Langara College
• 依托单位国家: 加拿大
• 项目类别: Applied Research and Development Grants - Level 1
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680705
• 关键词: Exploring; Role; Copper; Inducing; Anticancer

In recent years, cancer immunotherapy has garnered a lot of attention as it has been achieving great success in clinical trials. Immunotherapy improves patient outcomes by harnessing the bodies ability to overcome cancer using the patient's own defence mechanisms. However, not all of these novel vaccines and chemical agents are able to elicit an immune response in all cancer patients In fact in some patients, these therapies have shown to induce an adverse reaction. For this reason, it is important to identify novel methods of improving immune function in all patients with cancers without the risk for toxicity. Recently, CPI discovered that certain metals, specifically copper, could enhance immune system function. CPI has hypothesized that copper can be used in combination with other immune system inducing therapies or even traditional chemotherapeutics help to improve survival in patients with cancers that do not respond to single therapies alone. The objective of this proposal is to define how copper is able to augment the anti-cancer immune response, and then to combine copper with other chemotherapies of interest in order to define the best possible treatment strategies for patients with intractable disease.

近年来，癌症免疫疗法因其在临床试验中取得巨大成功而受到广泛关注。免疫疗法通过利用患者自身的防御机制来利用身体战胜癌症的能力来改善患者的预后。然而，并非所有这些新型疫苗和化学试剂都能够在所有癌症患者中引发免疫应答。事实上，在一些患者中，这些疗法已显示出诱导不良反应。因此，重要的是要确定改善所有癌症患者免疫功能的新方法，而没有毒性风险。最近，CPI发现某些金属，特别是铜，可以增强免疫系统功能。CPI假设铜可以与其他免疫系统诱导疗法或甚至传统的化疗药物联合使用，以帮助改善对单一疗法没有反应的癌症患者的生存率。该提案的目的是确定铜如何能够增强抗癌免疫应答，然后将铜与其他感兴趣的化疗联合收割机结合，以确定难治性疾病患者的最佳治疗策略。