Host response modulation results in altered Ebola virus replication and transcription kinetics in immune-privileged testis, which facilitates asymptomatic and persistent infections that may affect reproductive health and sexual transmission

宿主反应调节导致免疫特权睾丸中埃博拉病毒复制和转录动力学改变，从而促进无症状和持续感染，可能影响生殖健康和性传播

• 批准号: 418113
• 负责人: Webb Andrew L
• 金额: $ 7.65万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-10-01 至 2022-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=418113&lang=en
• 关键词: Ebola Virus; Host Response; Immune Privilege; Kinomics; Persistent Infection; Rna Sequencing; Testicular Infection; Transcriptomics; Viral Replication

The current Ebola virus disease outbreak in the Democratic Republic of Congo has resulted in more than 2,900 infections and 1,900 fatalities, with no end in sight. This outbreak is already the second largest in history; the largest only ended three years

刚果民主共和国目前爆发的埃博拉病毒病已导致2900多人感染和1900人死亡，而且看不到结束的迹象。这场疫情已经是历史上第二大疫情；最大的疫情只结束了三年。