CSHL 2023 Conference on Microbial Pathogenesis & Host Response

微生物致病机理和宿主反应 2023年9月11日至15日 摘要 第十四届微生物发病机制和宿主反应国际会议将重点讨论 跨学科的方法来研究传染病，整合分子微生物学学科， 真核细胞生物学、免疫学和基因组学。微生物疾病再次成为重要的 由于新的病原体的出现，常见病毒的重新上升， 病原体和广泛的耐药性。在人类健康之外，毁灭性的流行病正在破坏稳定 生态系统，棕色蝙蝠和两栖动物目前处于极端威胁之下。会议将提供一个- 深入关注正在被用来阐明细菌和真菌的机制的方法， 发病机制，并促进这些概念的应用，以控制和干预的新策略 传染性疾病。口头和海报会议将集中在微生物发病机制的主要新兴主题 和宿主反应，包括：微生物疾病的发病机制，宿主的分子调控， 病原体相互作用，宿主细胞/病原体相互作用生物学，以及病原体逃避策略的多样性 先天免疫会议将整合细菌和真菌病原体的研究。口头会议将 开始时，邀请该领域的知名领导人进行2-3次会谈，然后进行几次简短的会谈， 提交摘要。个别会议的广泛主题包括：（1）微生物毒素和效应物在 微生物疾病;（2）感染过程中的基本细胞生物学相互作用，（3）先天免疫反应， （4）宿主-微生物相互作用的关键分子调节;（5）健康中的微生物群落 和疾病，以及（6）使用最先进的技术来可视化宿主-病原体相互作用。列入 两个海报会议以及分配充足的时间为问题后，每个演讲将鼓励 与会者进行了广泛的讨论。会议规模不大（250-350名科学家）， 这些互动，但足够大，不仅允许口头介绍，从建立调查， 也来自初级研究人员和那些有新观点的人。各种各样的方面的整合 细菌和真菌的致病机理与宿主对病原体的反应应促进新的跨学科 在其他关于微生物发病机理的会议上很少实现的相互作用， 集中或如此多样化的主题是具有挑战性的整合。由此产生的跨学科互动将 促进制定否则可能无法实现的概念和实验方法。

Microbial Pathogenesis and Host Response September 11 – 15, 2023 ABSTRACT The fourteenth international conference on Microbial Pathogenesis and Host Response will focus on interdisciplinary approaches to study infectious disease, integrating the disciplines of molecular microbiology, eukaryotic cell biology, immunology, and genomics. Microbial diseases have once again taken an important central role in health care worldwide, due to the emergence of new pathogens, the re-ascent of common pathogens, and extensive drug resistance. Outside of human health, devastating pandemics are destabilizing ecosystems, with brown bats and amphibians currently under extreme threat. The meeting will provide an in- depth focus on the approaches that are being used to elucidate the mechanisms of bacterial and fungal pathogenesis, and promote the application of these concepts to novel strategies for the control and intervention of infectious diseases. Oral and poster sessions will focus on major emerging themes of microbial pathogenesis and the host response, including: the pathogenesis of microbial diseases; the molecular regulation of host- pathogen interactions, host cell/pathogen interaction biology, and the diversity of pathogen strategies to evade innate immunity. The sessions will integrate studies on bacterial and fungal pathogens. The oral sessions will begin with 2-3 invited talks by established leaders in the field, followed by several shorter talks chosen from submitted abstracts. Broad themes for individual sessions include: (1) role of microbial toxins and effectors in microbial diseases; (2) fundamental cell biological interactions during infection, (3) innate immune responses to microbial infection’ (4) key molecular regulation of host-microbial interactions; (5) microbial communities in health and disease, and (6) using state-of-the art technologies to visualize host-pathogen interactions. The inclusion of two poster sessions as well as the allotment of ample time for questions following each talk will encourage extensive discussion between the participants. The meeting will be small enough (250-350 scientists) to facilitate these interactions, yet large enough to allow for oral presentations not only from established investigators, but also from junior investigators and those with novel perspectives. The integration of a wide variety of aspects of bacterial and fungal pathogenesis with the host response to pathogens should promote new interdisciplinary interactions that are seldom achieved at other meetings on microbial pathogenesis that are either more narrowly focused or so diverse that the topics are challenging to integrate. The resulting interdisciplinary interactions will facilitate the development of conceptual and experimental approaches that might not otherwise be possible.