Rapid Separation and Quantitation of Isomeric Perfluoroalkyl Substances by Differential Mobility Spectrometry

通过差动迁移谱法快速分离和定量异构全氟烷基物质

• 批准号: 543502-2019
• 负责人: Hopkins, Scott
• 金额: $ 1.82万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=681084
• 关键词: Rapid; Separation; Quantitation; Isomeric; Perfluoroalkyl

Perfluorinated alkyl substances (PFASs) are a class of organic compounds that are widely used in many consumer products and industrial applications such as fire-redardant coatings for fabrics, fire-fighting foams, and food packaging. Owing to the inertness of C-F bonds, PFASs are persist essentially indefinitely in the environment and are commonly found at relatively high levels in soil and groundwater. Over the past two decades, concerns about PFASs have been increasing; these species can bioaccumulate and can adversely affect the health of marine life and potentially humans. Since the year 2000, PFASs have been found globally in, e.g., wildlife, human breast milk, and the blood of the general human population.One of the key challenges in the identification and quantitation of PFASs is the separation of linear and branched chain species. The position and length of the carbon chain has been demonstrated to impact bioaccumulation potential and the toxicity of PFASs to rodents. The current state-of-the-art methods for isomeric PFAS analysis requires analysis times of ca. 15-60 minutes per sample and consumes relatively large amounts of solvent and/or gas. Here, we propose to develop a faster, low-waste analysis technique for PFASs, based on differential mobility spectrometry coupled with mass spectrometry. The proposed analytical technique will improve our ability to detect and monitor environmental PFAS contaminants, and aid in the process of soil and groundwater remediation.

全氟烷基物质（PFAS）是一类广泛用于许多消费品和工业应用的有机化合物，如织物的阻燃涂层，消防泡沫和食品包装。由于C-F键的惰性，PFAS基本上无限期地存在于环境中，并且通常在土壤和地下水中含量相对较高。在过去二十年中，人们对全氟辛烷磺酸的担忧不断增加;这些物种可以生物积累，并可能对海洋生物和人类的健康产生不利影响。自2000年以来，PFAS已在全球范围内发现，例如，PFAS的鉴定和定量的关键挑战之一是直链和支链物质的分离。碳链的位置和长度已被证明会影响全氟辛烷磺酸的生物累积潜力和对啮齿动物的毒性。目前同分异构体PFAS分析的最新方法要求分析时间约为10分钟。每个样品需要15-60分钟，并且消耗相对大量的溶剂和/或气体。在这里，我们建议开发一种更快，低浪费的PFASs分析技术，基于差分迁移率光谱结合质谱。所提出的分析技术将提高我们检测和监测环境PFAS污染物的能力，并有助于土壤和地下水修复过程。