Quantum dot lighting solutions for optogenetics and precision growth of photosynthetic organisms

阳光影响昼夜节律，调节人类生物过程和行为的时间。传统的办公室和电脑照明不遵循这个周期，扰乱我们的生物钟的性能，影响我们的睡眠。这会影响表现、情绪和健康。Nano-Lit Technologies开发了一种与量子点LED照明系统相结合的控制系统，为客户提供满足我们生物需求的上级照明系统。照明行业目前面临的最大挑战是量化地证明受控照明对健康、睡眠质量和能量水平的功效。该研究项目将基于Nano-Lit的核心技术开发一个实验室规模的照明系统，使我们能够使用光合生物和光遗传学中依赖于光的遗传电路，作为植物和动物（包括人类）中存在的遗传电路的代理，以高通量测试生物体对量子点照明的响应。我们将设计、开发和测试基于量子点的照明解决方案，这些解决方案可以集成到哈勒姆实验室的Labcyte Access Workstation高通量筛选仪器中，从而实现多达40，320个克隆培养物的自动化平板接种、孵育和平行监测。这些努力将为Nano-Lit提供有关其量子点LED照明系统功效的定量信息。

Sunlight influences circadian rhythms that regulate the timing of biological processes and behaviour in humans. Conventional office and computer lighting does not follow this cycle, upsetting the performance of our biological clock and affecting our sleep. This effects performance, mood and health. Nano-Lit Technologies has developed a control system that works in combination with a Quantum Dot LED lighting system to provide customers superior lighting systems for our biological needs. The most significant challenge currently facing the lighting industry is quantifiably proving the efficacy of controlled lighting on health, sleep quality and energy levels. This research project will develop a laboratory-scale lighting system based onNano-Lit's core technology that will enable us to test organismal responsiveness to quantum dot lighting in high-throughput, using the light-dependant genetic circuits in photosynthetic organisms and optogenetics, as proxies for those that exist in plants and animals, including humans. We will design, develop and test quantum dot-based lighting solutions that can be integrated into the Labcyte Access Workstation high-throughput screening instrumentation in the Hallam lab, enabling automated plating, incubation and monitoring of up to 40,320 clonal cultures in parallel. These efforts will provide Nano-Lit with quantitative information on the efficacy of their Quantum Dot LED lighting system.