Quantum dot lighting solutions for optogenetics and precision growth of photosynthetic organisms

用于光遗传学和光合生物精准生长的量子点照明解决方案

• 批准号: 544075-2019
• 负责人: Hallam, Steven
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=681080
• 关键词: Quantum; dot; lighting; solutions; optogenetics

Sunlight influences circadian rhythms that regulate the timing of biological processes and behaviour in humans. Conventional office and computer lighting does not follow this cycle, upsetting the performance of our biological clock and affecting our sleep. This effects performance, mood and health. Nano-Lit Technologies has developed a control system that works in combination with a Quantum Dot LED lighting system to provide customers superior lighting systems for our biological needs. The most significant challenge currently facing the lighting industry is quantifiably proving the efficacy of controlled lighting on health, sleep quality and energy levels. This research project will develop a laboratory-scale lighting system based onNano-Lit's core technology that will enable us to test organismal responsiveness to quantum dot lighting in high-throughput, using the light-dependant genetic circuits in photosynthetic organisms and optogenetics, as proxies for those that exist in plants and animals, including humans. We will design, develop and test quantum dot-based lighting solutions that can be integrated into the Labcyte Access Workstation high-throughput screening instrumentation in the Hallam lab, enabling automated plating, incubation and monitoring of up to 40,320 clonal cultures in parallel. These efforts will provide Nano-Lit with quantitative information on the efficacy of their Quantum Dot LED lighting system.

阳光影响昼夜节律，调节人类生物过程和行为的时间。传统的办公室和电脑照明不遵循这个周期，扰乱我们的生物钟的性能并影响我们的睡眠。这会影响表现、情绪和健康。 Nano-Lit Technologies 开发了一种与量子点 LED 照明系统结合使用的控制系统，为客户提供满足我们生物需求的卓越照明系统。照明行业目前面临的最重大挑战是量化证明受控照明对健康、睡眠质量和能量水平的功效。该研究项目将开发一个基于 Nano-Lit 核心技术的实验室规模照明系统，使我们能够利用光合生物和光遗传学中的光依赖性遗传电路，作为植物和动物（包括人类）中存在的遗传电路的代表，以高通量测试生物体对量子点照明的反应。我们将设计、开发和测试基于量子点的照明解决方案，这些解决方案可以集成到 Hallam 实验室的 Labcyte Access Workstation 高通量筛选仪器中，从而能够并行自动电镀、孵化和监测多达 40,320 个克隆培养物。这些努力将为 Nano-Lit 提供有关其量子点 LED 照明系统功效的定量信息。