Role and regulatory mechanisms of pre- versus post-synaptic mRNA translation in memory formation and retrieval within glutamatergic neurons of an intact neural circuit

完整神经回路谷氨酸能神经元内突触前与突触后 mRNA 翻译在记忆形成和检索中的作用和调节机制

• 批准号: 412292
• 负责人: Cagnetta Roberta
• 金额: $ 9.83万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-10-01 至 2022-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=412292&lang=en
• 关键词: Adeno-Associated Virus-Based Gene Targeting 'In Vivo'; Fluorescence Activated Synaptosome Sorting 'In Vivo'; Glutamatergic Neurons; Local Mrna Translation; Memory Formation And Retrieval; Neural Circuit Maintenance And Remodelling; Pre- And Post-Synaptic

One of the most fundamental properties of the brain is the ability to make and recall memories, from minutes to years. The incidence of memory impairment (~8% among Canadians aged 75 and older) is escalating with population aging. To tackle this problem i

大脑最基本的特性之一是制造和回忆记忆的能力，从几分钟到几年。随着人口老龄化，记忆障碍的发生率（75岁及以上加拿大人约8%）正在上升。为了解决这个问题，我