Role and regulatory mechanisms of pre- versus post-synaptic mRNA translation in remote memory recall at single neuron type resolution 'in vivo'

突触前与突触后 mRNA 翻译在单神经元类型分辨率“体内”远程记忆回忆中的作用和调节机制

• 批准号: 473841
• 负责人: Cagnetta Roberta
• 金额: $ 3.28万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2023-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=473841&lang=en
• 关键词: Adeno-Associated Virus-Based Gene Targeting 'In Vivo'; Local Mrna Translation; Memory Reconsolidation; Neural Circuit Maintenance And Remodelling; Parvalbumin-Expressing Interneurons; Pre- And Post-Synaptic Terminals; Remote Memory Recall; Ribosome Profil

A fundamental property of the brain is the ability to make and recall memories. The incidence of memory impairment (~8% among Canadians aged 75 and older) is escalating with population aging. To tackle this problem it is fundamental to understand the mole

大脑的一个基本特性是制造和回忆记忆的能力。随着人口老龄化，记忆障碍的发生率（75岁及以上加拿大人约8%）正在上升。为了解决这个问题，了解鼹鼠是至关重要的