Landscape ecology of the deer tick and its associated Lyme disease pathogen

鹿蜱及其相关莱姆病病原体的景观生态学

基本信息

  • 批准号:
    RGPIN-2019-04730
  • 负责人:
  • 金额:
    $ 2.04万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2019
  • 资助国家:
    加拿大
  • 起止时间:
    2019-01-01 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

Lyme disease is caused by the bacterium Borrelia burgdorferi, which is carried by a range of vertebrate reservoir hosts and transmitted to people and animals by infected tick vectors. In Canada, the incidence of Lyme disease is increasing rapidly in association with the northward range expansion of the deer tick (Ixodes scapularis). Despite the growing importance of Lyme disease in many parts of Canada, many aspects of Lyme disease ecology remain unclear, especially in areas of recent introduction. This includes knowledge on the geographic distribution of the tick and pathogen, the importance of different species as hosts for ticks and Lyme disease, and the pathways of tick and pathogen spread at the landscape scale. This research aims to: 1) determine the host range and prevalence of B. burgdorferi in free-ranging mammals and ticks through field studies; 2) understand the ecological determinants of reservoir host, vector and pathogen niche through ecological modelling; 3) characterize the genetic diversity of reservoir hosts, vectors and pathogens through molecular studies; and, 4) investigate potential pathways of tick and Lyme disease spread using population and landscape genetics. My proposed research combines field studies of reservoir hosts and tick vectors, molecular and genetic characterization of reservoir hosts, vectors and pathogens, and spatial and statistical modelling in order to better understand Lyme disease ecology and spread in peri-urban environments situated at the northern range front of deer tick invasion. These studies will increase our understanding of the involvement of small mammal reservoir hosts and tick vectors in B. burgdorferi transmission and spread, and reveal how Lyme disease transmission patterns are affected by environmental factors. Furthermore, these studies will identify factors associated with the spread of deer ticks and B. burgdorferi in a region of recent Lyme disease introduction. Notably, this research will help to inform vector-borne disease surveillance and control strategies, which will ultimately reduce disease spread and prevent infections in domestic animals and humans. **
莱姆病是由伯氏疏螺旋体引起的,它由一系列脊椎动物宿主携带,并通过受感染的蜱虫传播给人和动物。在加拿大,莱姆病的发病率正在迅速增加,这与鹿蜱(肩突硬蜱)向北的范围扩张有关。尽管莱姆病在加拿大的许多地区越来越重要,但莱姆病生态的许多方面仍然不清楚,特别是在最近引入的地区。这包括蜱虫和病原体的地理分布,不同物种作为蜱虫和莱姆病宿主的重要性,以及蜱虫和病原体在景观尺度上传播的途径。本研究的目的是:1)确定B的宿主范围和流行情况。本研究的目的是:(1)通过野外研究,了解莱姆病在自由放养的哺乳动物和蜱类中的传播途径;(2)通过生态建模,了解宿主、病媒和病原体生态位的生态决定因素;(3)通过分子研究,描述宿主、病媒和病原体的遗传多样性;(4)利用种群和景观遗传学,调查蜱类和莱姆病传播的潜在途径。我建议的研究结合了水库主机和蜱虫载体,水库主机,载体和病原体的分子和遗传特征,空间和统计建模,以更好地了解莱姆病生态学和传播位于鹿蜱入侵的北方范围前的城市周边环境的实地研究。这些研究将增加我们对B中小哺乳动物储毒宿主和蜱媒的参与的理解。莱姆病的传播和蔓延,并揭示如何传播模式受环境因素的影响。此外,这些研究将确定与鹿蜱和B传播相关的因素。最近莱姆病传入的一个地区。值得注意的是,这项研究将有助于为病媒传播疾病的监测和控制战略提供信息,最终减少疾病传播并预防家畜和人类感染。**

项目成果

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Kulkarni, Manisha其他文献

What caused the 2012 dengue outbreak in Pucallpa, Peru? A socio-ecological autopsy
  • DOI:
    10.1016/j.socscimed.2016.12.010
  • 发表时间:
    2017-02-01
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    Charette, Margot;Berrang-Ford, Lea;Kulkarni, Manisha
  • 通讯作者:
    Kulkarni, Manisha
Factors associated with maternity waiting home use among women in Jimma Zone, Ethiopia: a multilevel cross-sectional analysis
  • DOI:
    10.1136/bmjopen-2018-028210
  • 发表时间:
    2019-08-01
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Kurji, Jaameeta;Gebretsadik, Lakew Abebe;Kulkarni, Manisha
  • 通讯作者:
    Kulkarni, Manisha

Kulkarni, Manisha的其他文献

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{{ truncateString('Kulkarni, Manisha', 18)}}的其他基金

Landscape ecology of the deer tick and its associated Lyme disease pathogen
鹿蜱及其相关莱姆病病原体的景观生态学
  • 批准号:
    RGPIN-2019-04730
  • 财政年份:
    2022
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Landscape ecology of the deer tick and its associated Lyme disease pathogen
鹿蜱及其相关莱姆病病原体的景观生态学
  • 批准号:
    RGPIN-2019-04730
  • 财政年份:
    2021
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Landscape ecology of the deer tick and its associated Lyme disease pathogen
鹿蜱及其相关莱姆病病原体的景观生态学
  • 批准号:
    RGPIN-2019-04730
  • 财政年份:
    2020
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Landscape ecology of the deer tick and its associated Lyme disease pathogen
鹿蜱及其相关莱姆病病原体的景观生态学
  • 批准号:
    DGECR-2019-00234
  • 财政年份:
    2019
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Launch Supplement
Entomological evaluation of malaria vectors in Kilimanjaro region, North East Tanzania
坦桑尼亚东北部乞力马扎罗地区疟疾病媒的昆虫学评估
  • 批准号:
    304313-2004
  • 财政年份:
    2005
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Entomological evaluation of malaria vectors in Kilimanjaro region, North East Tanzania
坦桑尼亚东北部乞力马扎罗地区疟疾病媒的昆虫学评估
  • 批准号:
    304313-2004
  • 财政年份:
    2004
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
PGSA
前列腺素A
  • 批准号:
    244015-2001
  • 财政年份:
    2003
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Postgraduate Scholarships
PGSA
前列腺素A
  • 批准号:
    244015-2001
  • 财政年份:
    2002
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Postgraduate Scholarships
PGSA
前列腺素A
  • 批准号:
    244015-2001
  • 财政年份:
    2001
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Postgraduate Scholarships

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评估美国中南部木本植物入侵对蜱传病原体的影响
  • 批准号:
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Landscape ecology of the deer tick and its associated Lyme disease pathogen
鹿蜱及其相关莱姆病病原体的景观生态学
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Landscape ecology of the deer tick and its associated Lyme disease pathogen
鹿蜱及其相关莱姆病病原体的景观生态学
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