Chiral Systems Chemistry

手性系统化学

• 批准号: RGPIN-2019-07031
• 负责人: Cuccia, Louis
• 金额: $ 2.11万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=683027
• 关键词: Chiral; Systems; Chemistry

Chiral Systems Chemistry ******Louis Pasteur is best known for the process of pasteurization', typically associated with milk purification, but Pasteur's contribution to Chemistry is probably more far reaching. In 1848, Pasteur separated mirror image crystals of sodium ammonium tartrate tetrahydrate based solely on visual inspection, and in the process inaugurated the intriguing topic of molecular asymmetry. Chirality, or handedness, is part of our everyday lives and its importance is particularly evident in the pharmaceutical industry, the agrochemical industry, and the food industry. The global market for chiral technology-enabling products is projected to reach $9.1 billion by 2022. Chiral preference for one handedness of biomolecules is a characteristic of living systems, but the origin of biological homochirality is one of the outstanding mysteries facing scientists, where a precise explanation has yet to be found. ******Systems Chemistry' can be broadly defined as, the emergence of order from chaos'. Conglomerate crystallization of achiral molecules into chiral crystals provides a unique opportunity to investigate chiral systems chemistry'. Experiments in our lab have shown that under attrition conditions in a process called Viedma ripening', a wide variety of conglomerate crystals of achiral molecules can be reliably driven to homochirality. The evolution of our research will involve delving deeper into chiral systems chemistry' to understand the hierarchical nature of chiral crystallization and self-assembly. Our multi-tiered approach encompasses: (i) the implementation of modern mechanochemical techniques to facilitate Viedma ripening, (ii) the investigation of enantiomer-specific oriented attachment (ESOA), (iii) the exploration of chiral crystallization and helical morphogenesis in gels and (iv) the examination of mirror symmetry breaking and chiral amplification in supramolecular systems.******Our research program is not only of critical importance for the pharmaceutical and agrochemical industries, but also addresses the profound question as to the origins of biological homochirality, an essential molecular characteristic of terrestrial life'. Furthermore, our studies on crystallization from gels may contribute to a better understanding of biomineralization, including pathological deposition of crystals (i.e. crystal deposition diseases).*****

手性系统化学******路易斯·巴斯德最出名的是巴氏消毒过程，通常与牛奶净化有关，但巴斯德对化学的贡献可能更深远。1848年，巴斯德仅凭目视检查就分离出了四水合物酒石酸铵钠的镜像晶体，并在此过程中开创了分子不对称的有趣课题。手性或手性是我们日常生活的一部分，其重要性在制药工业、农用化学工业和食品工业中尤为明显。到2022年，全球手性技术支持产品市场预计将达到91亿美元。生物分子对单手性的手性偏好是生命系统的一个特征，但生物同手性的起源是摆在科学家面前的一个突出的谜团，其中一个精确的解释尚未找到。******系统化学‘可以被广泛地定义为，从混乱中出现秩序’。非手性分子的砾岩结晶成手性晶体为研究手性系统化学提供了一个独特的机会。我们实验室的实验表明，在一种称为“Viedma成熟”的过程中，在摩擦条件下，各种各样的非手性分子的砾岩晶体可以可靠地被驱动成同手性。我们研究的发展将涉及更深入地研究手性系统化学，以了解手性结晶和自组装的层级性。我们的多层方法包括：(i)实施现代机械化学技术以促进Viedma成熟，（ii）研究对映体特异性定向附着（ESOA）， （iii）探索凝胶中的手性结晶和螺旋形态发生，以及（iv）检查超分子系统中的镜像对称破断和手性扩增。******我们的研究计划不仅对制药和农用化学工业至关重要，而且还解决了关于生物同手性起源的深刻问题，这是陆地生命的基本分子特征。此外，我们对凝胶结晶的研究可能有助于更好地理解生物矿化，包括晶体的病理沉积（即晶体沉积病）。*****