Regulation of systemic and reproductive tract inflammation in dairy cows

奶牛全身和生殖道炎症的调节

• 批准号: RGPIN-2015-04209
• 负责人: Leblanc, Stephen
• 金额: $ 2.4万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=684977
• 关键词: Regulation; systemic; reproductive; tract; inflammation

This research program will benefit the nearly 1 million lactating dairy cows on 13,000 dairy farms in Canada, and many more in the global dairy industry, approximately one-third of which have their fertility reduced by some form of reproductive tract disease each year. While these conditions are generally not considered to reduce animal welfare directly, they are economically costly to producers, and failure to become pregnant will ultimately cause a cow to be removed from the herd.***Inflammation is a necessary part of uterine healing after calving, but*if inflammation is excessive or persistent it may be harmful rather than*helpful. It appears that systemic inflammation due to metabolism*outside the reproductive tract (i.e. fat mobilization and liver*function) may be at least as important as the local interactions of*bacteria and inflammatory response in the reproductive tract. However,*the contribution of metabolic inflammation remains to be quantified and*this is a target of the present research program. To do so will require a better understanding of the relationships between feed intake, energy supply, and inflammation.***The objectives of this research program are: ***1. To describe the relationship between the common decrease in feed intake and increased indicators of systemic inflammation in the last weeks of pregnancy in dairy cows***2. To establish the ability and utility of strategic anti-inflammatory therapy to reduce metabolic and reproductive tract inflammation ***3. To investigate the ability of improved energy supply in early lactation to improve inflammatory status***Over the five years of this research program, we will conduct three intensive studies which build on each other to achieve the objectives.  We will use validated, minimally-invasive markers of energy metabolism, inflammation, immune function, and reproductive tract tract health to try to disentangle decreases in feed intake and increases in whole-body inflammation and to test whether anti-inflammatory therapy can relieve undesirable symptoms of these.  Next we will establish proof of concept that systemic anti-inflammatory treatment can helpfully reduce inflammation in the reproductive tract.  Finally we will investigate the separate and joint effects of reducing inflammation and providing increased energy supply on whole-body and local reproductive inflammation and health.  This program will train 2 graduate and 6 undergraduate students in a wide variety of scientific techniques that will position them well for science-based careers in the growing and increasingly sophisticated animal agriculture sector of the Canadian economy.**

该研究计划将使加拿大 13,000 个奶牛场的近 100 万头泌乳奶牛以及全球乳制品行业的更多奶牛受益，其中每年约有三分之一的奶牛的生育能力因某种形式的生殖道疾病而降低。虽然这些情况通常不被认为会直接降低动物福利，但它们对生产者来说在经济上代价高昂，并且未能怀孕最终将导致奶牛被从牛群中剔除。***炎症是产犊后子宫愈合的必要部分，但*如果炎症过度或持续，它可能有害而不是*有益。看来，由于生殖道外代谢*（即脂肪动员和肝脏*功能）引起的全身炎症可能至少与*细菌和生殖道炎症反应的局部相互作用一样重要。然而，*代谢炎症的贡献仍有待量化，*这是当前研究计划的目标。为此，需要更好地了解采食量、能量供应和炎症之间的关系。***本研究计划的目标是：***1。描述奶牛妊娠最后几周采食量普遍下降与全身炎症指标增加之间的关系***2。建立战略性抗炎治疗减少代谢和生殖道炎症的能力和效用***3。调查哺乳早期改善能量供应以改善炎症状态的能力***在本研究计划的五年中，我们将进行三项深入研究，这些研究相辅相成以实现目标。  我们将使用经验证的、微创的能量代谢、炎症、免疫功能和生殖道健康标记物来尝试解决采食量减少和全身炎症增加的问题，并测试抗炎治疗是否可以缓解这些不良症状。  接下来，我们将建立概念证明，证明全身抗炎治疗有助于减少生殖道炎症。  最后，我们将研究减少炎症和增加能量供应对全身和局部生殖炎症和健康的单独和联合影响。  该计划将为 2 名研究生和 6 名本科生提供各种科学技术方面的培训，使他们能够在加拿大经济中不断发展和日益复杂的动物农业领域从事基于科学的职业。 **