Regulation of systemic and reproductive tract inflammation in dairy cows

奶牛全身和生殖道炎症的调节

• 批准号: RGPIN-2015-04209
• 负责人: LeBlanc, Stephen
• 金额: $ 2.4万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656930
• 关键词: Regulation; systemic; reproductive; tract; inflammation

This research program will benefit the nearly 1 million lactating dairy cows on 13,000 dairy farms in Canada, and many more in the global dairy industry, approximately one-third of which have their fertility reduced by some form of reproductive tract disease each year. While these conditions are generally not considered to reduce animal welfare directly, they are economically costly to producers, and failure to become pregnant will ultimately cause a cow to be removed from the herd.***Inflammation is a necessary part of uterine healing after calving, but*if inflammation is excessive or persistent it may be harmful rather than*helpful. It appears that systemic inflammation due to metabolism*outside the reproductive tract (i.e. fat mobilization and liver*function) may be at least as important as the local interactions of*bacteria and inflammatory response in the reproductive tract. However,*the contribution of metabolic inflammation remains to be quantified and*this is a target of the present research program. To do so will require a better understanding of the relationships between feed intake, energy supply, and inflammation.***The objectives of this research program are: ***1. To describe the relationship between the common decrease in feed intake and increased indicators of systemic inflammation in the last weeks of pregnancy in dairy cows***2. To establish the ability and utility of strategic anti-inflammatory therapy to reduce metabolic and reproductive tract inflammation ***3. To investigate the ability of improved energy supply in early lactation to improve inflammatory status***Over the five years of this research program, we will conduct three intensive studies which build on each other to achieve the objectives.  We will use validated, minimally-invasive markers of energy metabolism, inflammation, immune function, and reproductive tract tract health to try to disentangle decreases in feed intake and increases in whole-body inflammation and to test whether anti-inflammatory therapy can relieve undesirable symptoms of these.  Next we will establish proof of concept that systemic anti-inflammatory treatment can helpfully reduce inflammation in the reproductive tract.  Finally we will investigate the separate and joint effects of reducing inflammation and providing increased energy supply on whole-body and local reproductive inflammation and health.  This program will train 2 graduate and 6 undergraduate students in a wide variety of scientific techniques that will position them well for science-based careers in the growing and increasingly sophisticated animal agriculture sector of the Canadian economy.**

这项研究计划将使加拿大13，000个奶牛场的近100万头泌乳奶牛受益，全球乳制品行业的奶牛数量更多，其中约三分之一每年因某种形式的生殖道疾病而降低生育能力。虽然这些情况通常不被认为会直接降低动物福利，但对生产者来说，它们在经济上是昂贵的，而且未能怀孕最终会导致奶牛从牛群中被淘汰。炎症是产犊后子宫愈合的必要组成部分，但如果炎症过度或持续，可能有害而无益。由于生殖道外的代谢 *（即脂肪动员和肝功能）引起的全身性炎症似乎至少与生殖道内细菌和炎症反应的局部相互作用一样重要。然而，* 代谢性炎症的贡献仍有待量化，* 这是目前研究计划的目标。要做到这一点，需要更好地了解饲料摄入量，能量供应和炎症之间的关系。本研究的目的是：**1。描述奶牛在妊娠最后几周内采食量普遍减少与全身炎症指标增加之间的关系 *2。建立战略性抗炎治疗减少代谢和生殖道炎症的能力和效用 *3。为了研究改善泌乳早期能量供应改善炎症状态的能力 * 在这项研究计划的五年中，我们将进行三项相互建立的深入研究，以实现目标。我们将使用经过验证的，微创的能量代谢，炎症，免疫功能，和生殖道健康，试图解开减少摄食量和增加全身炎症，并测试是否抗-炎症治疗可以缓解这些不良症状。接下来，我们将建立系统性抗-炎症治疗可以帮助减少生殖道炎症。最后，我们将研究减少炎症和增加生殖道炎症的单独和联合作用。能源供应对全身和局部生殖炎症和健康。该计划将培养2名研究生和6名本科生在各种各样的科学技术，这将使他们在加拿大经济的不断增长和日益复杂的畜牧业部门中以科学为基础的职业生涯。**