Regulation of sympathetic vasoconstriction in resting and contracting skeletal muscle

静息和收缩骨骼肌中交感血管收缩的调节

• 批准号: RGPIN-2015-04084
• 负责人: Delorey, Darren
• 金额: $ 2.91万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=687999
• 关键词: Regulation; sympathetic; vasoconstriction; resting; contracting

The precise regulation of blood pressure and the distribution of blood flow are essential to ensure that vital organs and tissues receive an adequate supply of oxygen and other nutrients. Blood pressure and tissue blood flow are controlled by carefully regulating resistance in arteries. Neural activity in the sympathetic nervous system leads to the release of chemicals (neurotransmitters) that constrict peripheral blood vessels and increase arterial resistance. Therefore, the sympathetic nervous system is an important regulator of blood pressure, tissue blood flow and vascular function. ****The long-term goal of my research program is to establish a mechanistic understanding of sympathetic nervous system regulation of blood pressure and skeletal muscle blood flow at rest, during exercise and in response to physiological stress. I am also interested in understanding how sympathetic nervous system control of the cardiovascular system can be enhanced and aim to identify stimuli that produce adaptations and the specific mechanisms that underlie the changes.****My laboratory uses an integrative physiology experimental approach in combination with pharmacology and molecular techniques to investigate mechanisms that regulate sympathetic neurovascular control and plasticity from the cellular to the integrated systems level.****The aims of the present research are to determine the effects of chronic aerobic exercise training on sympathetic nervous system activity and the mechanistic control of sympathetic vasoconstriction in resting and contracting skeletal muscle. The proposed studies pay particular attention to the dose-response relationship between exercise-training and neuro-vascular adaptations, as well as how the individual components of an exercise training program (e.g. intensity, duration of training) impact sympathetic vascular control. The proposed studies will also determine if sex is an important factor influencing sympathetic nervous system regulation of the cardiovascular system and the response to chronic exercise training.****This research will advance understanding of the important physiological mechanisms involved in sympathetic nervous system control of the cardiovascular system. The research will also have important biomedical implications with respect to the control of blood pressure and the perfusion of vital organs and tissues at rest and in response to physiological stress (e.g. acute and chronic exercise). ****The proposed studies utilize an array of cutting edge experimental techniques and an integrative scientific approach which provides a rich training environment. I will continue to engage undergraduate and graduate students in my research, and thus, the research will contribute to the development of the next generation of scientific personnel and future research innovation and excellence in Canada.***********

精确调节血压和血流分布对确保重要器官和组织获得足够的氧气和其他营养物质至关重要。血压和组织血流量是通过仔细调节动脉的阻力来控制的。交感神经系统的神经活动导致化学物质（神经递质）的释放，这些化学物质会收缩周围血管，增加动脉阻力。因此，交感神经系统是血压、组织血流量和血管功能的重要调节者。****我的研究计划的长期目标是建立一个机制的理解交感神经系统调节血压和骨骼肌血流量在休息，运动和生理应激的反应。我也有兴趣了解如何增强交感神经系统对心血管系统的控制，并旨在确定产生适应的刺激和变化背后的具体机制。****我的实验室使用综合生理学实验方法结合药理学和分子技术来研究从细胞到综合系统水平调节交感神经血管控制和可塑性的机制。****本研究的目的是确定慢性有氧运动训练对交感神经系统活动的影响，以及在休息和收缩骨骼肌时交感血管收缩的机制控制。拟议的研究特别关注运动训练和神经血管适应之间的剂量-反应关系，以及运动训练计划的各个组成部分（如强度、训练时间）如何影响交感血管控制。拟议的研究还将确定性别是否是影响心血管系统交感神经系统调节和对慢性运动训练反应的重要因素。****这项研究将促进对交感神经系统控制心血管系统的重要生理机制的理解。该研究还将对血压控制和重要器官和组织在休息时的灌注以及对生理应激（如急性和慢性运动）的反应具有重要的生物医学意义。****建议的研究利用一系列尖端的实验技术和综合科学方法，提供丰富的培训环境。我将继续让本科生和研究生参与我的研究，这样，我的研究将有助于加拿大下一代科学人才的发展和未来研究的创新和卓越。***********