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Design and evaluation of novel inhibitors targeting SARS-CoV-2 polymerase to create lead compounds to develop more effective treatments of COVID-19

Design and evaluation of novel inhibitors targeting SARS-CoV-2 polymerase to create lead compounds to develop more effective treatments of COVID-19
设计和评估针对 SARS-CoV-2 聚合酶的新型抑制剂，以创建先导化合物，从而开发更有效的 COVID-19 治疗方法
批准号：
422715
负责人：
Ng Kenneth K
金额：
$30.31万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
已结题
起止时间：
2020-02-01 至 2022-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=422715&lang=en
关键词：
Antiviral Therapeutics Enzyme Assay Enzyme Inhibitors Medicinal Chemistry Organic Synthesis Rna Polymerase Structure-Based Drug Design X-Ray Crystallography

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中文摘要
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英文摘要
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 produces a key enzyme, nsp12, essential for replicating the viral genome. In combination with the sequence of nsp12 from SARS-CoV-2, previous studies on closely related
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COVID-19 Variant Supplement - Design and evaluation of novel inhibitors targeting SARS-CoV-2 polymerase to create lead compounds to develop more effective treatments of COVID-19
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  • 项目类别：
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  • 资助金额：
    $3.64万
  • 财政年份：
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    University of Calgary
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