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Targeting neutrophil-exosome regulated changes in tissue stiffness as a promoter of breast cancer liver metastasis

Targeting neutrophil-exosome regulated changes in tissue stiffness as a promoter of breast cancer liver metastasis
靶向中性粒细胞外泌体调节的组织硬度变化作为乳腺癌肝转移的促进剂
批准号：
422060
负责人：
Moraes Christopher
金额：
$4.37万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
已结题
起止时间：
2020-02-01 至 2022-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=422060&lang=en
关键词：
Extracellular Matrix Extracellular Vesicles Mechanobiology Neutrophil Extracellular Traps Neutrophils Stiffness

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中文摘要
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英文摘要
Increased tissue stiffness has previously been implicated as an important driver of cancer metastasis in primary and secondary tumors. However, the biological mechanisms by which tissues stiffen during cancer progression remain unclear. Neutrophils have
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会议论文
Reconceptualizing cancer metastasis as a balance of intra-tumoural mechanical forces
  • 批准号：
    388210
  • 项目类别：
    Operating Grants
  • 资助金额：
    $4.52万
  • 财政年份：
    2018
  • 负责人：
    Moraes Christopher
  • 依托单位：
    McGill University
Respiratory airway injury arising from rupture of occluding liquid plugs: identifying physical mechanisms causing idiopathic pulmonary fibrosis
  • 批准号：
    256083
  • 项目类别：
    Fellowship Programs
  • 资助金额：
    $3.64万
  • 财政年份：
    2012
  • 负责人：
    Moraes Christopher
  • 依托单位：
    University of Michigan (Ann Arbor)
海外基金