New mechanisms regulating the biogenesis of extracellular vesicles

调节细胞外囊泡生物发生的新机制

• 批准号: DP240101427
• 负责人: Prof Sharad Kumar
• 金额: $ 45.52万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101427
• 关键词: New; mechanisms; regulating; biogenesis; extracellular

Extracellular vesicles are small packages that contain active components derived from the cell of origin. These vesicles, released by most cell types, are critical for communication between cells. However, the processes of their formation and release remain poorly understood. This project aims to explore how ubiquitination, a type of protein modification system, controls the production of extracellular vesicles. Using a strong collaborative team and highly innovative approaches, the project will generate new knowledge to inform how cells communicate. Expected outcomes include knowledge of broad significance to cell biology, that can be leveraged to develop extracellular vesicles as tools for various biotechnology applications in the future.

细胞外囊泡是含有来源于细胞的活性成分的小包装。这些由大多数细胞类型释放的囊泡对于细胞之间的通信至关重要。然而，它们的形成和释放过程仍然知之甚少。本项目旨在探索泛素化（一种蛋白质修饰系统）如何控制细胞外囊泡的产生。通过强大的协作团队和高度创新的方法，该项目将产生新的知识来告知细胞如何通信。预期成果包括对细胞生物学具有广泛意义的知识，这些知识可用于开发细胞外囊泡，作为未来各种生物技术应用的工具。