Functional Polymers and Capsules

功能聚合物和胶囊

基本信息

  • 批准号:
    RGPIN-2016-06526
  • 负责人:
  • 金额:
    $ 3.35万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2019
  • 资助国家:
    加拿大
  • 起止时间:
    2019-01-01 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

My research involves the development of reactive, multi-responsive polymers and their use in a biomaterials context, including therapeutic cell encapsulation and in cell research. A major focus is on preparing pairs of water-soluble polymers that spontaneously react with each other to form cell-compatible hydrogels. Some of these polymers have cationic and anionic charges that allow them to be coated onto cell-containing calcium alginate capsules, where electrostatic attraction enhances their covalent cross-coupling. The resulting, covalently reinforced cell-containing capsules, are designed for long-term transplantation into, e.g., peritoneal cavities of patients suffering from hormone deficiency disorders such as insulin-dependant Diabetes. These capsules need to balance four requirements: 1. be permeable enough to allow nutrient and insulin diffusion, 2. provide a physical barrier to protect the encapsulated cells from the hosts' immune system, 3. be non-inflammatory themselves, and 4. resist degradation for one year. Current state-of-the-art capsules are largely based on polycation-coated calcium alginate, derived from seaweed, that elicit inflammatory and immune responses due to the polycation, as well as biocontaminants and inflammatory motifs in the alginate. We were able to demonstrate that crosslinked synthetic hydrogel coatings can reduce the hosts' immune response, attributed to both physical shielding of the alginate, and to the strongly hydrophilic nature of these hydrogel coatings due to the presence of excess carboxylate anions. ***We have since generated a suite of reactive polymers based on polyelectrolytes and polyampholytes with inherently anti-fouling properties. Some of these polymers can form liquid coacervates under physiological conditions, which should enable new modes of deposition onto cell-containing capsules: we will explore depositing liquid coacervates onto calcium alginate capsules, followed by in-situ crosslinking, to form unique micron-range crosslinked shells that may cover the small but critical fraction of cells always protruding from alginate capsules. Some of these polyampholytes have promise as non-cytotoxic cryoprotectants for low temperature storage of stem cells and red blood cells. We further have identified synthetic polymers that may replace alginate in the cell-containing hydrogel core, and will test if they are amenable to crosslinked overcoating, or indeed can be made to spontaneously crosslink once in capsule form. In addition, we have developed giant (10 - 40 micron) monodisperse hydrogel beads formed by precipitation polymerization, that have potential as cell mimics or supports in 3D cell cultures. Our work ranges from fundamental polymer research, to collaboration with stem cell researchers and diabetes researcher/clinicians, aiming to bring synthetic polymers to bear on growing biomedical needs.**
我的研究涉及反应性,多响应聚合物的开发及其在生物材料中的应用,包括治疗性细胞封装和细胞研究。一个主要重点是制备成对的水溶性聚合物,这些聚合物自发地相互反应形成细胞相容的水凝胶。这些聚合物中的一些具有阳离子和阴离子电荷,这使得它们能够被涂覆到含有细胞的藻酸钙胶囊上,其中静电吸引增强了它们的共价交叉偶联。所得到的共价增强的含细胞的胶囊被设计用于长期移植到例如,患有激素缺乏症如胰岛素依赖型糖尿病的患者的腹膜腔。这些胶囊需要平衡四个要求:1.具有足够的渗透性以允许营养和胰岛素扩散,2.提供物理屏障以保护包封的细胞免受宿主免疫系统的影响,3.本身不具有炎症性,以及4.抗降解一年。目前最先进的胶囊主要基于源自海藻的聚阳离子涂覆的藻酸钙,其由于聚阳离子以及藻酸盐中的生物污染物和炎性基序而引起炎症和免疫应答。我们能够证明交联的合成水凝胶涂层可以降低宿主的免疫应答,这归因于藻酸盐的物理屏蔽和由于过量羧酸根阴离子的存在而导致的这些水凝胶涂层的强亲水性。*** 此后,我们开发了一系列基于聚电解质和两性聚电解质的反应性聚合物,具有固有的防污性能。这些聚合物中的一些可以在生理条件下形成液体凝聚体,这应该能够实现沉积到含有细胞的胶囊上的新模式:我们将探索将液体凝聚体沉积到藻酸钙胶囊上,然后原位交联,以形成独特的微米范围交联壳,其可以覆盖总是从藻酸盐胶囊突出的小但关键的细胞部分。这些聚两性电解质中的一些有望作为干细胞和红细胞低温储存的非细胞毒性冷冻保护剂。我们还鉴定了可以在含细胞的水凝胶芯中替代藻酸盐的合成聚合物,并将测试它们是否适合于交联的外涂层,或者确实可以在胶囊形式中自发交联。此外,我们已经开发了通过沉淀聚合形成的巨大(10 - 40微米)单分散水凝胶珠,其具有作为3D细胞培养物中的细胞模拟物或支持物的潜力。我们的工作范围从基础聚合物研究,到与干细胞研究人员和糖尿病研究人员/临床医生的合作,旨在使合成聚合物能够满足日益增长的生物医学需求。

项目成果

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Stover, Harald其他文献

Stover, Harald的其他文献

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{{ truncateString('Stover, Harald', 18)}}的其他基金

Functional Polymers and Colloids
功能聚合物和胶体
  • 批准号:
    RGPIN-2021-04214
  • 财政年份:
    2022
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Colloids
功能聚合物和胶体
  • 批准号:
    RGPIN-2021-04214
  • 财政年份:
    2021
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2020
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2018
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2017
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2016
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional polymers and microspheres
功能聚合物和微球
  • 批准号:
    89661-2006
  • 财政年份:
    2006
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Synthesis and study of functional polymers
功能聚合物的合成与研究
  • 批准号:
    89661-2001
  • 财政年份:
    2005
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Synthesis and study of functional polymers
功能聚合物的合成与研究
  • 批准号:
    89661-2001
  • 财政年份:
    2004
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Synthesis and study of functional polymers
功能聚合物的合成与研究
  • 批准号:
    89661-2001
  • 财政年份:
    2003
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2020
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2018
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2017
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Polymers and Capsules
功能聚合物和胶囊
  • 批准号:
    RGPIN-2016-06526
  • 财政年份:
    2016
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional polymers and capsules for innovative paper products
用于创新纸制品的功能聚合物和胶囊
  • 批准号:
    250306-2011
  • 财政年份:
    2015
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Syntheses and functions of coordination polymers that transform to molecular capsules
转化为分子胶囊的配位聚合物的合成和功能
  • 批准号:
    15K05450
  • 财政年份:
    2015
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Functional polymers and capsules for innovative paper products
用于创新纸制品的功能聚合物和胶囊
  • 批准号:
    250306-2011
  • 财政年份:
    2014
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional polymers and capsules for innovative paper products
用于创新纸制品的功能聚合物和胶囊
  • 批准号:
    250306-2011
  • 财政年份:
    2013
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional polymers and capsules for innovative paper products
用于创新纸制品的功能聚合物和胶囊
  • 批准号:
    250306-2011
  • 财政年份:
    2012
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
Functional polymers and capsules for innovative paper products
用于创新纸制品的功能聚合物和胶囊
  • 批准号:
    250306-2011
  • 财政年份:
    2011
  • 资助金额:
    $ 3.35万
  • 项目类别:
    Discovery Grants Program - Individual
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