Natural Product Synthesis and Synthetic Methodology

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The aim of my research is to develop synthetic methods 25,917. Each of these natural products represents structural types with important biological properties (MPC1001 is extremely potent in in vitro tests against a prostate cancer cell line; coleophomone inhibits therapeutically relevant enzymes; sorbicillactone A is neuroprotective; CP 225,917 has biological activities relevant to the design of anticancer forming an eleven-membered ring, which is an easier process e MPC molecules will undoubtedly require the invention of new chemistry in response to the unusual behavior of the relevant intermediate structures, lop a general route to alkoxyalkynes (ROCCR') & methods for making benzenes from esters in a way that incorporates the ester carbonyl carbon into the benzene ringa process that will be useful in preparing drugs for treating diabetes.**