Natural Product Synthesis and Synthetic Methodology

天然产物合成及合成方法

• 批准号: RGPIN-2016-04503
• 负责人: Clive, Derrick
• 金额: $ 3.35万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=689337
• 关键词: Natural; Product; Synthesis; Synthetic; Methodology

The aim of my research is to develop synthetic methods 25,917. Each of these natural products represents structural types with important biological properties (MPC1001 is extremely potent in in vitro tests against a prostate cancer cell line; coleophomone inhibits therapeutically relevant enzymes; sorbicillactone A is neuroprotective; CP 225,917 has biological activities relevant to the design of anticancer forming an eleven-membered ring, which is an easier process e MPC molecules will undoubtedly require the invention of new chemistry in response to the unusual behavior of the relevant intermediate structures, lop a general route to alkoxyalkynes (ROCCR') & methods for making benzenes from esters in a way that incorporates the ester carbonyl carbon into the benzene ringa process that will be useful in preparing drugs for treating diabetes.**

我研究的目的是开发合成方法25，917. 这些天然产物中的每一种都代表了具有重要生物学特性的结构类型（MPC 1001在体外试验中对前列腺癌细胞系极其有效;鞘氨醇抑制治疗相关酶;山梨酸内酯A具有神经保护作用; CP 225，917具有与抗癌形成十一元环的设计相关的生物活性，这是一个更容易的过程，MPC分子无疑需要发明新的化学来响应相关中间结构的不寻常行为，切断烷氧基炔（ROCCR '）的一般路线&以将酯羰基碳引入苯环的方式从酯制备苯的方法，该方法将用于制备治疗糖尿病的药物。