Organic and Organometallic Chemistry

在过去的50年里，改善人类生活质量的药理活性物质的发展产生了巨大的社会影响。然而，由于临床候选药物成功率低而导致的药物发现成本的增加，促使人们认真分析导致失败率的因素。历史上，天然产品已被证明是药物发现的可靠先导化合物。然而，许多公司已经放弃了这种方法，因为与准备进行结构活性关系研究的类似物相关的问题。该程序为快速构建与药理学相关的基序提供了新的工具，从而绕过了类似系统之间的翻译问题。

The development of pharmacologically active agents that improve the quality of human life has had an enormous societal impact over the last 50 years. Nevertheless, the increasing cost of drug discovery due to the low success rate of clinical candidates has prompted serious analysis of the factors that contribute to the the failure rate. Natural products have historically proven reliable lead compounds for drug discovery. Nevertheless, many companies have abandoned this approach due to the problems associated with the preparation of analogs to conduct Structure Activity Relationship Studies. This program provides new tools for the expeditious construction of pharmacologically relevant motifs, which circumvent the problems with translation between analogous systems.