Organic and Organometallic Chemistry

有机和有机金属化学

• 批准号: 1000228134-2011
• 负责人: Evans, Andrew
• 金额: $ 3.64万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=690079
• 关键词: Organic; Organometallic; Chemistry

The development of pharmacologically active agents that improve the quality of human life has had an enormous societal impact over the last 50 years. Nevertheless, the increasing cost of drug discovery due to the low success rate of clinical candidates has prompted serious analysis of the factors that contribute to the the failure rate. Natural products have historically proven reliable lead compounds for drug discovery. Nevertheless, many companies have abandoned this approach due to the problems associated with the preparation of analogs to conduct Structure Activity Relationship Studies. This program provides new tools for the expeditious construction of pharmacologically relevant motifs, which circumvent the problems with translation between analogous systems.

在过去的50年里，改善人类生活质量的药物的开发产生了巨大的社会影响。 然而，由于临床候选药物的成功率低，药物发现的成本不断增加，这促使人们认真分析导致失败率的因素。 天然产物在历史上被证明是药物发现的可靠先导化合物。 然而，许多公司已经放弃了这种方法，由于与制备类似物进行结构活性关系研究的问题。 该程序提供了新的工具，快速建设的相关图案，它规避了类似系统之间的翻译问题。