Organic And Organometallic Chemistry

有机和有机金属化学

• 批准号: CRC-2018-00022
• 负责人: Evans, PAndrew
• 金额: $ 14.57万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=730295
• 关键词: Organic; Organometallic; Chemistry

The development of pharmacologically active agents that improve the quality and longevity of human life has had an enormous societal impact on society. Nevertheless, the inherent limitations associated with the tools utilized to discover these agents has hampered the development of new medicines, which also impacts new agrochemicals, materials, etc. For instance, the preparation of a new pharmacophore in a predictable manner requires versatile tools that permit the exploration of three-dimensional space in a systematic manner. This program delineates the development of new bond-forming reactions, which access hitherto underdeveloped/explored structural motifs that are medicinally important.

提高人类生活质量和寿命的药物的开发对社会产生了巨大的社会影响。 然而，与用来发现这些代理的工具相关的固有限制阻碍了新药的开发，这也影响了新的农用化学品，材料等。例如，以可预测的方式制备新的药效团需要多功能的工具，允许以系统的方式探索三维空间。 该计划描述了新的键形成反应的发展，这些反应进入了迄今为止尚未开发/探索的具有医学重要性的结构基序。