Developmental Neurobiology

运动精度最终取决于单个神经元和突触水平上运动回路的分辨率。然而，其他因素如肌肉质量/数量和关节灵活性也会影响运动。此外，在大多数生物体中，目前的突触标记技术没有足够的分辨率来区分相邻神经元之间的突触。因此，尚不清楚运动回路的精细程度在多大程度上决定了身体的能力。利用具有简单运动回路的遗传模式生物秀丽隐杆线虫，我将研究突触模式的分子机制及其如何影响运动。

Movement precision is ultimately determined by the resolution of the motor circuit at the level of single neurons and synapses. However, other factors such as muscle quality/quantity and joint flexibility also affect locomotion. In addition, current synaptic labeling techniques in most organisms do not have enough resolution to distinguish synapses between neighboring neurons. Hence, it is not clear to what extent the fineness of the motor circuit determines physical ability. Using a genetic model organism Caenorhabditis elegans, which has a simple locomotion circuit, I will study molecular mechanisms of synapse patterning and how it affects locomotion.