Developmental Neurobiology

运动精度最终由单个神经元和突触水平上的运动回路的分辨率决定。然而，其他因素，如肌肉质量/数量和关节灵活性也会影响运动。此外，目前大多数生物体中的突触标记技术没有足够的分辨率来区分相邻神经元之间的突触。因此，运动回路的精细程度在多大程度上决定了身体能力，这一点并不清楚。利用具有简单运动回路的遗传模式生物秀丽隐杆线虫，我将研究突触模式的分子机制及其如何影响运动。

Movement precision is ultimately determined by the resolution of the motor circuit at the level of single neurons and synapses. However, other factors such as muscle quality/quantity and joint flexibility also affect locomotion. In addition, current synaptic labeling techniques in most organisms do not have enough resolution to distinguish synapses between neighboring neurons. Hence, it is not clear to what extent the fineness of the motor circuit determines physical ability. Using a genetic model organism Caenorhabditis elegans, which has a simple locomotion circuit, I will study molecular mechanisms of synapse patterning and how it affects locomotion.