Multi-user in vivo animal imaging system

多用户活体动物成像系统

• 批准号: RTI-2020-00305
• 负责人: Rahim, MirMunir
• 金额: $ 10.93万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693792
• 关键词: Multi; user; vivo; animal; imaging

The University of Windsor has a growing number of NSERC funded young faculty dependent on imaging for their research programs. Currently, the entire Windsor region lacks any capacity for fluorescence/luminescence imaging of whole animals/plants and tissues. Acquisition of a core facility in vivo/ex vivo imager with capabilities to image a wide range of different colours with high quality resolution is absolutely essential to facilitate the success of the research and training of the programs described in this application. In the immediate term this equipment will facilitate the research needs of the entire Faculty of Science and Faculty of Engineering at the University of Windsor. Hence, the areas of science it encompasses are diverse; from cellular and molecular biology/biochemistry/genetics studying areas such as how organisms develop, how animal and plant cells grow, divide and regulate cell death in normal and abnormal situations, how the immune system recognizes self from non-self, to physiological questions relating to how animals process sound and how this controls important responses to the external environment. Programs in computer science, physics and chemistry rely on in vivo assessment of drug availability and fluorophore availability and this equipment will enable comparative studies for new development of MRI equipment. Collectively, obtaining in vivo/ex vivo imaging capacity in the Windsor region would accelerate a vast number of research projects and would support the training and success of more than 150 HQP in the next 6 years.

温莎大学有越来越多的NSERC资助的年轻教师依赖于成像的研究计划。目前，整个温莎地区缺乏对整个动物/植物和组织进行荧光/发光成像的能力。获取能够以高质量分辨率对各种不同颜色进行成像的核心设施体内/体外成像仪对于促进本申请中描述的项目的研究和培训的成功是绝对必要的。在短期内，该设备将促进温莎大学整个科学学院和工程学院的研究需要。因此，它所涵盖的科学领域是多种多样的;从细胞和分子生物学/生物化学/遗传学研究领域，如生物体如何发育，动物和植物细胞如何生长，在正常和异常情况下分裂和调节细胞死亡，免疫系统如何从非自我中识别自我，到与动物如何处理声音以及如何控制对外部环境的重要反应有关的生理问题。计算机科学、物理学和化学课程依赖于药物可用性和荧光团可用性的体内评估，该设备将使MRI设备新开发的比较研究成为可能。总的来说，在温莎地区获得体内/体外成像能力将加速大量研究项目，并将在未来6年内支持150多名HQP的培训和成功。