Multi-modal Tracking of In Vivo Skeletal Structures and Implants

体内骨骼结构和植入物的多模式跟踪

• 批准号: 10839518
• 负责人: Joseph J Crisco
• 金额: $ 25.62万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10839518
• 关键词: 3-Dimensional; Activities of Daily Living; Affect; Algorithmic Analysis; Algorithms; Architecture; Archives; Bone structure; Calibration; Code; Collaborations; Communities; Computer software; Consensus; Data; Data Files; Data Management Resources; Data Set; Databases; Development; Dimensions; Disease; Ecosystem; Educational workshop; Engineering; FAIR principles; Freedom; Funding; Future; Goals; Gold; Human; Image; Implant; Institution; Joints; Measures; Medical Imaging; Metadata; Methodology; Methods; Motion; Musculoskeletal; Musculoskeletal Diseases; Online Systems; Output; Parents; Persons; Plug-in; Replacement Arthroplasty; Research; Roentgen Rays; Site; Software Engineering; Standardization; Structure; System; Technology; Testing; Training; Translating; Translations; Universities; Update; Validation; Visualization; Work; Writing; bone; clinical practice; data access; data and analysis portal; data management; data repository; data sharing; data standards; database structure; design; experience; falls; four-dimensional computed tomography; graphical user interface; human subject; image registration; image visualization; imaging modality; imaging program; in vivo; joint function; kinematics; multimodality; novel; open source; open source library; parent project; programs; repository; research and development; secondary analysis; sharing platform; skeletal; software development; tool; tool development; treatment effect; user-friendly; web site

PROJECT SUMMARY The goal of the parent project is to develop an extensible, open-source software program for image-based skeletal and implant motion tracking that will compute six degree-of-freedom skeletal kinematics from biplane videoradiography (BVR), 3DCT, or 4DCT image datasets. The parent project partners teams at three academic institutions with software engineers at Kitware, Inc., an experienced and extremely capable open-source software development company, to refine and enhance Autoscoper, an existing open-source BVR software program, and integrate it into the Kitware-managed 3D Slicer ecosystem to yield SlicerAutoscoperM (SAM). In this project supplement we propose a new collaboration with research software engineers at Brown University to update and extend an existing online system designed to manage image-based zoological kinematic data – the X-ray Motion Analysis Portal (XMAPortal) – to create to create the Human Motion Analysis Portal (HMAPortal), a parallel system for managing and sharing SAM-compliant human kinematic data. The inputs for SAM consist of 10 or more files generated from 16 or more raw data and calibration files, and most of these files have associated metadata that are essential for analysis with SAM, such as video frame rate and CT voxel dimensions. It is crucial the files for SAM are organized in a standard format. This is especially important for the open sharing of human kinematic datasets among research groups, which is a major long-term goal of the parent project. When we wrote the parent proposal, we recognized that data management and sharing would present challenges, but developing those solutions was beyond the scope of our SAM software development. Updating and extending the XMAPortal to create the HMAPortal will make SAM datasets more findable, accessible, interoperable, and reusable, i.e., compliant with FAIR principles for data management and stewardship. The proposed project supplement falls within the scope of the parent project because managing and sharing SAM data among independent lab testing sites is part of the parent project's specific Aims 2 and 3. Development of the HMAPortal will create a much-needed template for the organization of legacy and new datasets (data and metadata), storage architecture, and data access tools. The specific Aims of this supplement are to: 1) collaborate with professional software engineers at Brown University to use robust software engineering practices to re-engineer and adapt the existing XMAPortal code to create the HMAPortal, a repository for SAM human kinematic datasets; 2) create HMAPortal data upload (HMAPortalupload) and download (HMAPortaldownload) plugins to translate and standardize datasets, thereby making these and all future datasets conform to FAIR data principles: findable, accessible, interoperable, and reusable; and 3) engage with the research community to develop consensus on data structures for the HMAPortal, through workshops that are already planned as part of the parent project.

项目摘要 母项目的目标是开发一个可扩展的，开源的软件程序， 骨骼和植入物运动跟踪，将从双平面计算六个自由度的骨骼运动学 视频放射摄影（BVR）、3DCT或4DCT图像数据集。母项目合作伙伴团队在三个学术 Kitware公司的软件工程师，一个经验丰富、能力极强的开源 软件开发公司，以完善和增强Autoscoper，现有的开源BVR软件 程序，并将其集成到Kitware管理的3D Slicer生态系统中，以生成SlicerAutoscoperM（SAM）。在 在这个项目的补充中，我们提议与布朗大学的研究软件工程师进行新的合作 更新和扩展现有的在线系统，旨在管理基于图像的动物学动态数据- X射线运动分析门户（XMAPortal）-创建人体运动分析门户 （HMAPortal），用于管理和共享符合SAM的人体运动学数据的并行系统。的投入 SAM由16个或更多原始数据和校准文件生成的10个或更多文件组成，其中大多数文件 具有对SAM分析至关重要的关联元数据，例如视频帧速率和CT体素 尺寸. SAM的文件必须以标准格式组织，这一点至关重要。这一点对于 在研究小组之间开放共享人体运动学数据集，这是母公司的主要长期目标 项目当我们编写母提案时，我们认识到数据管理和共享将 这些挑战，但开发这些解决方案超出了我们SAM软件开发的范围。更新 扩展XMAPortal以创建HMAPortal将使SAM数据集更易于查找、访问， 可互操作和可重用，即，符合FAIR数据管理和管理原则。的 拟议的项目补充福尔斯属于母项目的范围，因为管理和共享SAM 独立实验室测试站点之间的数据是母项目特定目标2和3的一部分。发展 HMAPortal将创建一个急需的模板，用于组织遗留和新数据集（数据和 元数据）、存储体系结构和数据访问工具。本补充文件的具体目的是：1） 与布朗大学的专业软件工程师合作，使用健壮的软件工程 重新设计和调整现有XMAPortal代码以创建SAM存储库HMAPortal的实践 人体运动学数据集; 2）创建HMAPortal数据上传（HMAPortalupload）和下载（HMAPortaldownload） 插件来翻译和标准化数据集，从而使这些和所有未来的数据集符合FAIR数据 原则：可查找、可访问、可互操作和可重复使用;以及3）与研究界合作， 通过已经计划的研讨会，就HMAPortal的数据结构达成共识， 的父项目。