Multi-modal Tracking of In Vivo Skeletal Structures and Implants

体内骨骼结构和植入物的多模式跟踪

• 批准号: 10839518
• 负责人: Joseph J Crisco
• 金额: $ 25.62万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10839518
• 关键词: 3-Dimensional; Activities of Daily Living; Affect; Algorithmic Analysis; Algorithms; Architecture; Archives; Bone structure; Calibration; Code; Collaborations; Communities; Computer software; Consensus; Data; Data Files; Data Management Resources; Data Set; Databases; Development; Dimensions; Disease; Ecosystem; Educational workshop; Engineering; FAIR principles; Freedom; Funding; Future; Goals; Gold; Human; Image; Implant; Institution; Joints; Measures; Medical Imaging; Metadata; Methodology; Methods; Motion; Musculoskeletal; Musculoskeletal Diseases; Online Systems; Output; Parents; Persons; Plug-in; Replacement Arthroplasty; Research; Roentgen Rays; Site; Software Engineering; Standardization; Structure; System; Technology; Testing; Training; Translating; Translations; Universities; Update; Validation; Visualization; Work; Writing; bone; clinical practice; data access; data and analysis portal; data management; data repository; data sharing; data standards; database structure; design; experience; falls; four-dimensional computed tomography; graphical user interface; human subject; image registration; image visualization; imaging modality; imaging program; in vivo; joint function; kinematics; multimodality; novel; open source; open source library; parent project; programs; repository; research and development; secondary analysis; sharing platform; skeletal; software development; tool; tool development; treatment effect; user-friendly; web site

PROJECT SUMMARY The goal of the parent project is to develop an extensible, open-source software program for image-based skeletal and implant motion tracking that will compute six degree-of-freedom skeletal kinematics from biplane videoradiography (BVR), 3DCT, or 4DCT image datasets. The parent project partners teams at three academic institutions with software engineers at Kitware, Inc., an experienced and extremely capable open-source software development company, to refine and enhance Autoscoper, an existing open-source BVR software program, and integrate it into the Kitware-managed 3D Slicer ecosystem to yield SlicerAutoscoperM (SAM). In this project supplement we propose a new collaboration with research software engineers at Brown University to update and extend an existing online system designed to manage image-based zoological kinematic data – the X-ray Motion Analysis Portal (XMAPortal) – to create to create the Human Motion Analysis Portal (HMAPortal), a parallel system for managing and sharing SAM-compliant human kinematic data. The inputs for SAM consist of 10 or more files generated from 16 or more raw data and calibration files, and most of these files have associated metadata that are essential for analysis with SAM, such as video frame rate and CT voxel dimensions. It is crucial the files for SAM are organized in a standard format. This is especially important for the open sharing of human kinematic datasets among research groups, which is a major long-term goal of the parent project. When we wrote the parent proposal, we recognized that data management and sharing would present challenges, but developing those solutions was beyond the scope of our SAM software development. Updating and extending the XMAPortal to create the HMAPortal will make SAM datasets more findable, accessible, interoperable, and reusable, i.e., compliant with FAIR principles for data management and stewardship. The proposed project supplement falls within the scope of the parent project because managing and sharing SAM data among independent lab testing sites is part of the parent project's specific Aims 2 and 3. Development of the HMAPortal will create a much-needed template for the organization of legacy and new datasets (data and metadata), storage architecture, and data access tools. The specific Aims of this supplement are to: 1) collaborate with professional software engineers at Brown University to use robust software engineering practices to re-engineer and adapt the existing XMAPortal code to create the HMAPortal, a repository for SAM human kinematic datasets; 2) create HMAPortal data upload (HMAPortalupload) and download (HMAPortaldownload) plugins to translate and standardize datasets, thereby making these and all future datasets conform to FAIR data principles: findable, accessible, interoperable, and reusable; and 3) engage with the research community to develop consensus on data structures for the HMAPortal, through workshops that are already planned as part of the parent project.

项目概要 父项目的目标是开发一个可扩展的开源软件程序，用于基于图像的 骨骼和植入物运动跟踪，将计算双平面的六个自由度骨骼运动学 放射影像 (BVR)、3DCT 或 4DCT 图像数据集。父项目合作伙伴团队来自三个学术机构 Kitware, Inc. 拥有软件工程师的机构，Kitware, Inc. 是一家经验丰富且能力极强的开源公司 软件开发公司，旨在完善和增强现有开源 BVR 软件 Autoscoper 程序，并将其集成到 Kitware 管理的 3D Slicer 生态系统中以生成 SlicerAutoscoperM (SAM)。在 在这个项目补充中，我们提议与布朗大学的研究软件工程师进行新的合作 更新和扩展现有的在线系统，旨在管理基于图像的动物运动学数据 – X 射线运动分析门户 (XMAPortal) – 创建人体运动分析门户 (HMAPortal)，用于管理和共享符合 SAM 的人体运动学数据的并行系统。输入为 SAM 由 16 个或更多原始数据和校准文件生成的 10 个或更多文件组成，其中大部分文件 具有 SAM 分析所必需的相关元数据，例如视频帧速率和 CT 体素 方面。以标准格式组织 SAM 文件至关重要。这对于 研究小组之间开放共享人体运动学数据集，这是家长的一个主要长期目标 项目。当我们编写父提案时，我们认识到数据管理和共享将呈现 挑战，但开发这些解决方案超出了我们 SAM 软件开发的范围。更新中 扩展 XMAPortal 以创建 HMAPortal 将使 SAM 数据集更易于查找、访问、 可互操作和可重用，即符合数据管理和管理的公平原则。这 拟议的项目补充属于父项目的范围，因为管理和共享 SAM 独立实验室测试站点之间的数据是父项目具体目标 2 和 3 的一部分。 HMAPortal 将为组织旧数据集和新数据集（数据和 元数据）、存储架构和数据访问工具。本补充的具体目标是： 1) 与布朗大学的专业软件工程师合作，使用强大的软件工程 重新设计和调整现有 XMAPortal 代码以创建 HMAPortal（SAM 存储库）的实践 人体运动学数据集； 2）创建HMAPortal数据上传（HMAPortalupload）和下载（HMAPortaldownload） 用于翻译和标准化数据集的插件，从而使这些和所有未来的数据集符合 FAIR 数据 原则：可查找、可访问、可互操作和可重用； 3）与研究界合作 通过已计划举办的研讨会，就 HMAPortal 的数据结构达成共识 父项目的。