Microbial catabolism and biocatalysis

微生物分解代谢和生物催化

• 批准号: CRC-2013-00042
• 负责人: Eltis, Lindsay
• 金额: $ 14.57万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694407
• 关键词: Microbial; catabolism; biocatalysis

Dr. Eltiss research has made major advances in understanding and harnessing the bacterial degradation of steroids and aromatic compounds, including lignin. This degradation is essential to the global carbon cycle and therefore to the health of the biosphere. Moreover, it is a rich source of biocatalysts for developing sustainable industrial processes. In Mycobacterium tuberculosis, cholesterol degradation has recently emerged as a potential drug target. Dr. Eltiss research will contribute to: paradigm-shifting insights into bacterial degradation, including the enzymes involved; urgently needed novel therapeutics for treating tuberculosis; and innovative biocatalysts and platforms to transform forest biomass into high-value products.

Eltiss博士的研究在理解和利用类固醇和芳香族化合物（包括木质素）的细菌降解方面取得了重大进展。这种退化对全球碳循环至关重要，因此对生物圈的健康至关重要。此外，它是开发可持续工业过程的生物催化剂的丰富来源。在结核分枝杆菌中，胆固醇降解最近成为一个潜在的药物靶点。Eltiss博士的研究将有助于：对细菌降解的范式转变见解，包括所涉及的酶;迫切需要的治疗结核病的新疗法;以及将森林生物质转化为高价值产品的创新生物催化剂和平台。