Biased agonism at G-protein coupled receptors: in vitro to in vivo

G 蛋白偶联受体的偏向激动：体外到体内

• 批准号: 433331
• 负责人: Clarke Paul B
• 金额: $ 65.48万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433331&lang=en
• 关键词: Behavioural Pharmacology; Dopaminergic Receptors; Fibre Photometry; G-Protein Coupled Receptors; In Vivo Biosensors; Intracellular Signalling Pathways; Mu Opioid Receptors

Drug discovery was historically based in animal models of disease- which while being a slow process, was fairly successful In the modern era, we have move away from experiments in animals, because of technologies that have allowed us to screen many more d

从历史上看，药物的发现是基于动物疾病模型的——虽然这是一个缓慢的过程，但相当成功。在现代，我们已经不再用动物做实验，因为技术使我们能够筛选更多的疾病