Organic Synthesis and Biocatalysis

我们的研究项目专注于通过将传统的有机合成方法与生物协议相结合，高效地制造具有重要药用价值的化合物，这是一种更高效、更环保、更少浪费的制造策略。它涉及吗啡生物碱的制备，包括半合成阿片衍生剂（镇痛药）；水芹素衍生物和多基因素A（抗癌剂）；和其他目标（加兰他敏）通过使用细菌，真菌，植物或哺乳动物的酶作为绿色替代品，使用危险或有毒的试剂。试剂开发，全合成，开发用于n -去甲基化的转基因生物，以及提供对映纯构建块和手性聚合物是我们生物催化项目的特点。

Our research program focuses on efficient manufacturing of medicinally importantcompounds by combining traditional organic synthesis methods with biological protocols, a strategy that leads to more efficient and environmentally conscious manufacturing with less waste. It addresses the preparation of morphine alkaloids, including semisynthetic opiate-derived agents (analgesics); pancratistatin derivatives and pleiogenone A (anticancer agents); and other targets (galanthamine) by using bacterial, fungal, plant, or mammalian enzymes as green alternatives to the use of hazardous or toxic reagents. Reagent development, total synthesis, development of transgenic organisms for N-demethylation, and provision of enantiopure building blocks and chiral polymers characterize our program in biocatalysis.