Organic Synthesis and Biocatalysis

我们的研究计划专注于通过将传统的有机合成方法与生物方案相结合来高效制造具有重要药用价值的化合物，这一策略可以用更少的废物实现更高效、更环保的制造。它涉及通过使用细菌、真菌、植物或哺乳动物酶作为使用危险或有毒试剂的绿色替代品来制备吗啡生物碱，包括半合成阿片衍生剂(止痛剂)、泛影抑素衍生物和多效酮A(抗癌剂)以及其他靶标(加兰他明)。试剂开发、全合成、用于N-脱甲基化的转基因生物的开发以及提供对映体构建块和手性聚合物是我们在生物催化方面的计划的特征。

Our research program focuses on efficient manufacturing of medicinally importantcompounds by combining traditional organic synthesis methods with biological protocols, a strategy that leads to more efficient and environmentally conscious manufacturing with less waste. It addresses the preparation of morphine alkaloids, including semisynthetic opiate-derived agents (analgesics); pancratistatin derivatives and pleiogenone A (anticancer agents); and other targets (galanthamine) by using bacterial, fungal, plant, or mammalian enzymes as green alternatives to the use of hazardous or toxic reagents. Reagent development, total synthesis, development of transgenic organisms for N-demethylation, and provision of enantiopure building blocks and chiral polymers characterize our program in biocatalysis.