Organic Synthesis and Biocatalysis

有机合成与生物催化

• 批准号: CRC-2016-00268
• 负责人: Hudlicky, Tomas
• 金额: $ 14.57万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695101
• 关键词: Organic; Synthesis; Biocatalysis

Our research program focuses on efficient manufacturing of medicinally importantcompounds by combining traditional organic synthesis methods with biological protocols, a strategy that leads to more efficient and environmentally conscious manufacturing with less waste. It addresses the preparation of morphine alkaloids, including semisynthetic opiate-derived agents (analgesics); pancratistatin derivatives and pleiogenone A (anticancer agents); and other targets (galanthamine) by using bacterial, fungal, plant, or mammalian enzymes as green alternatives to the use of hazardous or toxic reagents. Reagent development, total synthesis, development of transgenic organisms for N-demethylation, and provision of enantiopure building blocks and chiral polymers characterize our program in biocatalysis.

我们的研究计划侧重于通过将传统的有机合成方法与生物协议相结合来有效制造药用重要化合物，这是一种导致更高效，更环保，浪费更少的制造策略。它涉及通过使用细菌、真菌、植物或哺乳动物酶作为使用危险或有毒试剂的绿色替代品制备吗啡生物碱，包括半合成阿片衍生剂（镇痛剂）;泮托拉他汀衍生物和普莱奥酮A（抗癌剂）;以及其他靶标（加兰他敏）。试剂开发，全合成，N-去甲基化转基因生物的开发，以及提供对映体纯的结构单元和手性聚合物是我们在生物催化方面的特色。