Program in chemoenzymatic synthesis: Morphine and Amaryllidaceae alkaloids, chiral building blocks, and design of new asymmetric protocols and reagents

化学酶合成项目：吗啡和石蒜科生物碱、手性结构单元以及新的不对称方案和试剂的设计

• 批准号: 262022-2013
• 负责人: Hudlicky, Tomas
• 金额: $ 5.03万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594705
• 关键词: Program; chemoenzymatic; synthesis; Morphine; Amaryllidaceae

The central theme of our program involves a combination of chemical and biological methods to maximize efficiency in the manufacturing of important organic compounds. These range from natural products, their medicinally important unnatural derivatives, chiral building blocks and reagents, and chiral polymers. Emphasis is placed on brevity of design and environmentally benign ("green") execution. These goals are accomplished by multi-generational pursuit of the targets and continuous improvement in synthetic protocols. In addition, and through collaborations with industry, process improvement research is being conducted for compounds of commercial significance, for example, opiate-derived analgesics.

我们计划的中心主题涉及化学和生物方法的结合，以最大限度地提高生产重要有机化合物的效率。这些范围包括天然产物，其具有重要药用意义的非天然衍生物，手性构建块和试剂以及手性聚合物。重点放在简洁的设计和环保（“绿色”）执行。这些目标是通过对目标的多代追求和对合成方案的不断改进来实现的。此外，通过与工业界合作，正在对具有商业意义的化合物进行工艺改进研究，例如阿片衍生镇痛药。