Identifying the mechanisms that specify cell size in animal cells.

确定动物细胞中指定细胞大小的机制。

• 批准号: 1000231338-2016
• 负责人: Kafri, Ran
• 金额: $ 8.74万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695227
• 关键词: Identifying; mechanisms; specify; cell; size

Regularity of cell size is a classic signature of healthy epithelia while the loss of size regularity is a diagnostic of pleomorphic cancers. How are numerous individual cells within a tissue regulated to have the same size? In preliminary work, I identified evidence that regularity of cell size is the product of cell-size dependent signaling a signaling that selectively promotes growth of small cells while inhibiting growth in large cells. The aim of the current proposal is to identify the molecular components of the cell size sensor the mechanism of cell size dependent signaling events.

细胞大小的规律性是健康上皮的典型特征，而大小规律性的丧失是多形性癌症的诊断特征。一个组织中众多的单个细胞是如何调节成相同大小的？在初步工作中，我发现了细胞大小的规律性是细胞大小依赖信号的产物的证据，这种信号选择性地促进小细胞的生长，同时抑制大细胞的生长。目前的建议的目的是确定细胞大小传感器的分子成分，细胞大小依赖的信号事件的机制。