High-Resolution Modeling in Systems Biology
系统生物学中的高分辨率建模
基本信息
- 批准号:CRC-2015-00042
- 负责人:
- 金额:$ 14.57万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Canada Research Chairs
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The research program of the CRC in High-Resolution Modeling in Systems Biology aims to construct accurate, genome-scale, atomic-resolution three-dimensional structural models for nodes and edges within protein-protein interaction networks in model eukaryotic species, in human, and between proteins from different species. This is achieved by developing key enabling computational technologies for high-resolution systems biology, and by collaborating with leading experimental systems biologists. These high-resolution models of cell circuitry will be used to probe design principles of biological networks, and to elucidate systems-level mechanisms of both human infectious and genetic diseases.
CRC在系统生物学高分辨率建模中的研究计划旨在构建精确的,基因组规模的,原子分辨率的三维结构模型,用于模型真核生物物种,人类和不同物种蛋白质之间的蛋白质相互作用网络中的节点和边缘。这是通过开发高分辨率系统生物学的关键计算技术,并与领先的实验系统生物学家合作来实现的。这些高分辨率的细胞电路模型将用于探索生物网络的设计原理,并阐明人类传染病和遗传病的系统级机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xia, Yu其他文献
Antitumor and off-target effects of cholesterol-conjugated let-7a mimics in an orthotopic hepatocellular carcinoma xenograft nude mouse model.
- DOI:
10.1097/jbr.0000000000000103 - 发表时间:
2022-12 - 期刊:
- 影响因子:0
- 作者:
Guan, Jian;Liu, Mingyang;Li, Xin;Zhou, Liangrui;Dong, Xueyu;Dai, Wei;Xia, Yu;Yang, Tao;Guo, Shaojuan;Li, Xingqi;Han, Yehua;Luo, Yufeng - 通讯作者:
Luo, Yufeng
MiR-129-3p regulates ferroptosis in the liver of Selenium-deficient broilers by targeting SLC7A11.
- DOI:
10.1016/j.psj.2022.102271 - 发表时间:
2023-01 - 期刊:
- 影响因子:4.4
- 作者:
Zhang, Kaixin;Gu, Xuedie;Xia, Yu;Zhao, Xiaochun;Pervez, Ahmed Khoso;Li, Shu - 通讯作者:
Li, Shu
Oxalate Pushes Efficiency of CsPb(0.7) Sn(0.3) IBr(2) Based All-Inorganic Perovskite Solar Cells to over 14.
- DOI:
10.1002/advs.202106054 - 发表时间:
2022-04 - 期刊:
- 影响因子:15.1
- 作者:
Zhang, Weihai;Liu, Heng;Qi, Xingnan;Yu, Yinye;Zhou, Yecheng;Xia, Yu;Cui, Jieshun;Shi, Yueqing;Chen, Rui;Wang, Hsing-Lin - 通讯作者:
Wang, Hsing-Lin
Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy.
- DOI:
10.1186/s13045-022-01364-7 - 发表时间:
2022-10-25 - 期刊:
- 影响因子:28.5
- 作者:
Zhao, Binghao;Li, Huanzhang;Xia, Yu;Wang, Yaning;Wang, Yuekun;Shi, Yixin;Xing, Hao;Qu, Tian;Wang, Yu;Ma, Wenbin - 通讯作者:
Ma, Wenbin
LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal.
- DOI:
10.1186/s12935-022-02746-0 - 发表时间:
2022-10-29 - 期刊:
- 影响因子:5.8
- 作者:
Zhu, Guanghui;Xia, Yu;Zhao, Ziyue;Li, Aoyu;Li, Hui;Xiao, Tao - 通讯作者:
Xiao, Tao
Xia, Yu的其他文献
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{{ truncateString('Xia, Yu', 18)}}的其他基金
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
利用结构系统生物学模型探索蛋白质网络的高分辨率设计原理
- 批准号:
RGPIN-2019-05952 - 财政年份:2022
- 资助金额:
$ 14.57万 - 项目类别:
Discovery Grants Program - Individual
Computational and Systems Biology
计算和系统生物学
- 批准号:
CRC-2021-00424 - 财政年份:2022
- 资助金额:
$ 14.57万 - 项目类别:
Canada Research Chairs
High-Resolution Modeling in Systems Biology
系统生物学中的高分辨率建模
- 批准号:
CRC-2015-00042 - 财政年份:2022
- 资助金额:
$ 14.57万 - 项目类别:
Canada Research Chairs
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
利用结构系统生物学模型探索蛋白质网络的高分辨率设计原理
- 批准号:
RGPIN-2019-05952 - 财政年份:2021
- 资助金额:
$ 14.57万 - 项目类别:
Discovery Grants Program - Individual
High-Resolution Modeling In Systems Biology
系统生物学中的高分辨率建模
- 批准号:
CRC-2015-00042 - 财政年份:2021
- 资助金额:
$ 14.57万 - 项目类别:
Canada Research Chairs
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
利用结构系统生物学模型探索蛋白质网络的高分辨率设计原理
- 批准号:
RGPIN-2019-05952 - 财政年份:2020
- 资助金额:
$ 14.57万 - 项目类别:
Discovery Grants Program - Individual
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
利用结构系统生物学模型探索蛋白质网络的高分辨率设计原理
- 批准号:
RGPAS-2019-00012 - 财政年份:2020
- 资助金额:
$ 14.57万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
利用结构系统生物学模型探索蛋白质网络的高分辨率设计原理
- 批准号:
RGPAS-2019-00012 - 财政年份:2019
- 资助金额:
$ 14.57万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
High-Resolution Modeling in Systems Biology
系统生物学中的高分辨率建模
- 批准号:
CRC-2015-00042 - 财政年份:2019
- 资助金额:
$ 14.57万 - 项目类别:
Canada Research Chairs
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
利用结构系统生物学模型探索蛋白质网络的高分辨率设计原理
- 批准号:
RGPIN-2019-05952 - 财政年份:2019
- 资助金额:
$ 14.57万 - 项目类别:
Discovery Grants Program - Individual
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