Advanced Cell-instructive Materials and Biotherapeutics

先进的细胞指导材料和生物治疗学

• 批准号: CRC-2018-00028
• 负责人: Paul, Arghya
• 金额: $ 8.74万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695986
• 关键词: Advanced; Cell; instructive; Materials; Biotherapeutics

Injectable hydrogels have the potential to revolutionize both minimally invasive drug delivery, and 3D bioprinting, the automated production of tissues and organs. However, the effectiveness of conventional hydrogels is still limited by their suboptimal mechanical properties. Dr. Pauls research program will address these needs by developing a new class of nanocomposite hydrogels with high structural stability, printability, and ability to provide sustained delivery of therapeutics. This new material design will enable the engineering of living tissues whose shapes and biological activities can be patient-specific.

可注射水凝胶有可能彻底改变微创药物输送和3D生物打印，即组织和器官的自动化生产。然而，常规水凝胶的有效性仍然受到其次优机械性能的限制。Pauls博士的研究计划将通过开发一类具有高结构稳定性、可印刷性和提供持续治疗的能力的新型纳米复合水凝胶来满足这些需求。这种新材料设计将使活组织的工程化成为可能，其形状和生物活性可以是患者特异性的。