Age-associated macrophage dysfunction in atherosclerosis regression

动脉粥样硬化消退中年龄相关的巨噬细胞功能障碍

• 批准号: 434276
• 负责人: Ouimet Mireille I
• 金额: $ 57.4万
• 依托单位: University of Ottawa Heart Institute
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=434276&lang=en
• 关键词: Aging; Atherosclerosis; Autophagy; Cholesterol; Macrophages; Mitochondria

Advanced age is a risk factor for many chronic diseases, including atherosclerosis. However, how biological aging contributes to disease progression is poorly understood, yet could represent a significant opportunity for therapeutic intervention in older

高龄是许多慢性病的危险因素，包括动脉粥样硬化。然而，生物衰老如何促进疾病进展还知之甚少，但可能代表着对老年人进行治疗干预的一个重要机会。