The role of glycosphingolipids in the secretion and clearance of extracellular vesicles in brain health and disease

鞘糖脂在脑健康和疾病中细胞外囊泡的分泌和清除中的作用

• 批准号: 433798
• 负责人: Sipione Simonetta
• 金额: $ 75.79万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433798&lang=en
• 关键词: Animal Models; Biology Of Gangliosides; Cell Models; Extracellular Vesicles; Huntington'S Disease; Microglia; Neurodegeneration; Neuroinflammation; Sialic Acid Binding Proteins

Gangliosides are lipid molecules highly enriched in the healthy brain that play important roles in the communication among cells. During ageing and in certain neurodegenerative diseases, levels of gangliosides decrease and contribute to brain dysfunction.

神经节苷脂是在健康大脑中高度富集的脂质分子， 在细胞间的通讯中起着重要的作用。在衰老和某些神经退行性疾病中，神经节苷脂水平降低并导致脑功能障碍。