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A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system
脂滴在蛋白质稳态中的新作用:对神经系统错误折叠蛋白质疾病的影响
批准号:
468690
负责人:
Sipione Simonetta
金额:
$71.06万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-09-01 至 2027-09-01

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中文摘要
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英文摘要
Toxic proteins with abnormal shapes (misfolded) accumulate in the brain as we age and in many neurodegenerative disorders, including Huntington's disease, Parkinson's disease and Alzheimer's disease, inducing cellular stress. Healthy cells have many strat
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The role of glycosphingolipids in the secretion and clearance of extracellular vesicles in brain health and disease
  • 批准号:
    433798
  • 项目类别:
    Operating Grants
  • 资助金额:
    $75.79万
  • 财政年份:
    2020
  • 负责人:
    Sipione Simonetta
  • 依托单位:
Development of ganglioside-based therapies for Huntington's disease
  • 批准号:
    231670
  • 项目类别:
    Operating Grants
  • 资助金额:
    $11.6万
  • 财政年份:
    2011
  • 负责人:
    Sipione Simonetta
  • 依托单位:
Cellular lipids in Huntington's disease
  • 批准号:
    241199
  • 项目类别:
    Operating Grants
  • 资助金额:
    $0.0万
  • 财政年份:
    2011
  • 负责人:
    Sipione Simonetta
  • 依托单位:
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
  • 批准号:
    256327
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2011
  • 负责人:
    Sipione Simonetta
  • 依托单位:
海外基金