Investigating the role of accelerated neuronal aging in a mouse model of Huntington's disease from a circadian epigenomic perspective.

从昼夜节律表观基因组角度研究亨廷顿病小鼠模型中神经元加速衰老的作用。

• 批准号: 437792
• 负责人: Oh Gabriel Hyun Ta
• 金额: $ 7.29万
• 依托单位: Centre for Addiction and Mental Health (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=437792&lang=en
• 关键词: Circadian Epigenomics; Epigenetic Aging; Huntington'S Disease

Huntington's disease (HD) is a brain disease caused by an expansion of CAG nucleotide triplet in the huntingtin gene. The longer the CAG expansion, the earlier the onset of the disease. However, this DNA mutation does not fully explain the variability in

亨廷顿病（Huntington's disease，HD）是由亨廷顿基因中CAG核苷酸三联体扩增引起的脑部疾病。CAG扩张时间越长，疾病发作越早。然而，这种DNA突变并不能完全解释