Cutting down wait lists for organ transplants by pre-treatment of donor organs

通过对供体器官进行预处理，减少器官移植的等待名单

• 批准号: 549733-2020
• 负责人: Withers, Stephen
• 金额: $ 20.62万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699051
• 关键词: Cutting; down; wait; lists; organ

Waitlists for organ transplants are often extremely lengthy due to the need to identify available donor organs that are a good match to the patient requiring the transplant. This process of matching involves identifying organs that have similar external markers known as antigens, to those on the patients own tissues. Amongst the antigens that have to be matched are those that distinguish A, B and O type blood from each other. The relevant antigens on red blood cells are in fact very simple sugar molecules. A,B and O red blood cells all share a common substructure of sugars, but A and B red blood cells differ in each having one extra sugar attached. The applicants have recently developed a way of removing that additional sugar with enzymes so that they can convert A or B red blood cells to O type red blood cells. They are currently testing the safety of the Universal O type blood so developed. In this proposal the ability of these same enzymes to remove these antigens from the surface of donated human organs will be tested and the safety and use of the modified organs will be thoroughly tested. If successful this would allow the organs from A and B blood type individuals to be converted into O type organs. This would improve the odds of transplant patients obtaining matching organs, which would increase survival patient rates.

由于需要确定可用的器官，器官移植的等待名单通常非常长 与需要移植的患者匹配良好的捐赠器官。的过程 匹配包括识别具有称为抗原的相似外部标记的器官， 与患者自身组织上的DNA进行比对在必须匹配的抗原中， 区分A型、B型和O型血的基因。红色的相关抗原 血细胞实际上是非常简单的糖分子。A、B和O型红细胞都有一个共同的 糖的共同的子结构，但A和B红细胞不同，每个有一个额外的 糖附。申请人最近开发了一种方法， 糖与酶，使他们可以转换A或B红细胞为O型红细胞。 他们目前正在测试这样开发的通用O型血的安全性。在这 建议这些相同的酶的能力，以消除这些抗原从表面的 将对捐赠的人体器官进行测试，并将对改造后的器官的安全性和使用进行评估。 经过彻底测试。如果成功的话，A和B血型的器官 将个体转化为O型器官。这将提高移植的几率 患者获得匹配的器官，这将提高患者的存活率。