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Rational Design and Characterization of a Conformationally Stabilized Next-Generation Immunogen Against Malaria

Rational Design and Characterization of a Conformationally Stabilized Next-Generation Immunogen Against Malaria
构象稳定的下一代抗疟疾免疫原的合理设计和表征
批准号：
437188
负责人：
Thai Elaine
金额：
$10.93万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2020
资助国家：
加拿大
项目状态：
已结题
起止时间：
2020-11-01 至 2023-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=437188&lang=en
关键词：
Biolayer Interferometry Computational Protein Engineering Malaria Immunogen Design Negative-Stain Electron Microscopy Protein Expression Protein Modelling Protein Purification Protein Structural Biology Vaccine Development X-Ray Crystallography

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中文摘要
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英文摘要
Malaria is a global health concern and increasing resistance to current interventions has amplified the need for a potent vaccine. Antibodies (Abs) targeting circumsporozoite protein (CSP), a protein coating the surface of malaria parasites that mediates
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Rational Design and Characterization of a Conformationally Stabilized Next-Generation Immunogen Against Malaria
  • 批准号：
    440100
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $7.65万
  • 财政年份：
    2020
  • 负责人：
    Thai Elaine
  • 依托单位：
    Hospital for Sick Children (Toronto)
Structure-Based Design of Ubiquitin-Specific Protease 18 Inhibitors
  • 批准号：
    406463
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2018
  • 负责人：
    Thai Elaine
  • 依托单位：
    University of Toronto
海外基金