Rational Design and Characterization of a Conformationally Stabilized Next-Generation Immunogen Against Malaria

构象稳定的下一代抗疟疾免疫原的合理设计和表征

• 批准号: 437188
• 负责人: Thai Elaine
• 金额: $ 10.93万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-11-01 至 2023-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=437188&lang=en
• 关键词: Biolayer Interferometry; Computational Protein Engineering; Malaria Immunogen Design; Negative-Stain Electron Microscopy; Protein Expression; Protein Modelling; Protein Purification; Protein Structural Biology; Vaccine Development; X-Ray Crystallography

Malaria is a global health concern and increasing resistance to current interventions has amplified the need for a potent vaccine. Antibodies (Abs) targeting circumsporozoite protein (CSP), a protein coating the surface of malaria parasites that mediates

疟疾是一个全球性的健康问题，对目前干预措施的抵抗力不断增加，加大了对强效疫苗的需求。靶向环子孢子蛋白（CSP）的抗体（Abs），CSP是一种覆盖疟疾寄生虫表面的蛋白质，介导