Enhancing cell therapies using microfluidic encapsulation strategies

使用微流体封装策略增强细胞治疗

• 批准号: 549626-2020
• 负责人: Godin, Michel
• 金额: $ 24.09万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699979
• 关键词: Enhancing; cell; therapies; using; microfluidic

Cell-based therapies hold tremendous potential to repair damaged tissue but the central problem confronting ALL cell-based therapeutics lies in promoting meaningful long-term engraftment of transplanted cells. Recently, we developed a novel microfluidic platform to encapsulate cardiovascular progenitor cells in protective hydrogel cocoons, promoting cell viability while improving engraftment within injured tissue and providing markedly improved therapeutic benefits. However, this therapeutic effect is ultimately ephemeral as transplanted egress their protective hydrogel microcapsules rapidly and typically fail to be retained for more than a few additional days in the targeted tissue, thus limiting their full therapeutic impact. Our vision is to overcome these limitations by exploiting the ability of cell-type specific biomaterials and by using novel microencapsulation strategies to extend cell viability, while ensuring tissue persistence upon engraftment, ultimately promoting therapeutic repair of injured tissue. With broad implications in cellular therapeutics, we have found that this is particularly relevant to chronic lung disease of prematurity, the main complication of preterm birth, to the treatment of pulmonary arterial hypertension (PAH), and to cardiac injury repair, in which we have shown the protective effects of MSCs, EPCs and EDCs in vivo. We are working with Northern Therapeutics, a Canadian biotechnology company, to ensure this research will be widely applicable to the field of regenerative medicine, be of marked benefit to chronically ill patients, aide in the global competitiveness of a Canadian company, and stimulate economic development in Canada in an emerging new market.

细胞疗法在修复受损组织方面具有巨大的潜力