Mechanism of Metformin Action in the Small Intestine, Liver, and Brain

二甲双胍在小肠、肝脏和大脑中的作用机制

• 批准号: 441425
• 负责人: Zhang Song-Yang
• 金额: $ 9.83万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441425&lang=en
• 关键词: Energy Homeostasis; Gdf15; Glucose Homeostasis; Metformin

Diabetes is a major issue in Canada. About 11 million Canadians living with diabetes or prediabetes, and 90% of which are type II diabetes which is characterized by glucose intolerance and insulin resistance and associated with obesity. Metformin is the m

糖尿病是加拿大的一个主要问题。大约有1100万加拿大人患有糖尿病或糖尿病前期，其中90%是II型糖尿病，其特征是葡萄糖耐受不良和胰岛素抵抗，并与肥胖有关。Metabolism是M